1 ml of liquid and emulsion and 1 g of gel contain 10 mg of Clindamycin in the form of phosphate.
Action:
Lineosamide antibiotic in the form of a topical formulation. Works onPropionibacterium acnesbacteria that cause acne vulgaris. After repeated administration of clindamycin to the skin at a concentration corresponding to 10 mg / ml clindamycin in isopropyl alcohol and aqueous solution, a very low content of clindamycin in plasma (0-3 mg / ml) was observed and less than 0.2% of the dose of clindamycin was detected in the urine.
Contraindications:
Hypersensitivity to Clindamycin, Lincomycin or any of the excipients. Clindamycin in topical form is contraindicated in patients with colitis when using antibiotics.
Precautions:
The safety and efficacy of the medicine in children aged <12 years has not been established. Caution should be exercised in patients with Crohn's disease or ulcerative colitis. In any patient who has experienced diarrhea after antibiotic use, the risk of pseudomembranous colitis should be considered. Avoid contact of the preparation with eyes, mucous membranes and injured skin. The liquid and emulsion contain alcohol, which may cause redness or irritation of the eyes, mucous membranes or injured skin. The liquid and emulsion have a bitter taste and should be used with care in the mouth area. The liquid contains propylene glycol, the emulsion contains p-hydroxybenzoates and cetostearyl alcohol, the gel contains propylene glycol and methyl hydroxybenzoate - substances that can cause allergic reactions (also of late type) and local skin reactions. Use cautiously in patients with a tendency to allergy.
Pregnancy and lactation:
Clindamycin used systemically in the second and third trimester of pregnancy did not increase the incidence of congenital malformations, lack of adequate and well-controlled studies in women in the first trimester of pregnancy - use only in case of extreme necessity. Clindamycin passes into breast milk after oral or parenteral administration - due to the potential risk of side effects in breast-fed infants, discontinuation of breast-feeding or discontinuation of treatment should be considered, taking into account the benefit of treatment for the mother.
Side effects:
Drying, greasy skin, skin irritation and urticaria most often occur. Uncommon: gastrointestinal disorders. Not known: folliculitis caused by Gram-negative bacteria, eye pain, abdominal pain, pseudomembranous enteritis, contact dermatitis.
Dosage:
Outwardly. Adults and adolescents: apply a thin layer of liquid, emulsion or gel twice a day to affected areas (do not rub in).
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