Local treatment of moderate to severe forms of acne, where local treatment without antibiotics was not sufficient or not tolerated.
Composition:
1 ml of the final solution contains 40 mg of Erythromycin and 12 mg of zinc acetate as a complex of erythromycin with dihydrated micronized zinc acetate.
Action:
Anti-acne preparation for topical use. Erythromycin is a narrow spectrum antibacterial antibiotic belonging to macrolides. Microbes susceptible to this antibiotic include bacteria such asStaphylococcus epidermidis andPropionibacterium acnes. During treatment, resistance of the bacterial flora of the skin may occur, usually transient after discontinuation of treatment. After topical application, erythromycin is practically not absorbed into the systemic circulation or absorbed in a small amount. Zinc enhances the effect of erythromycin in the treatment of acne.
Contraindications:
Hypersensitivity to the preparation ingredients or other antibiotics from the macrolide group.
Precautions:
The drug is intended only for topical application to the skin. Avoid contact with the eyes or nasal mucosa of the mouth; in the event of accidental contact with eyes or mucous membranes, rinse thoroughly with water. Cross-resistance may occur with other antibiotics from the macrolide group and with Lincomycin and clindamycin. Cross-hypersensitivity between macrolides may also occur.
Pregnancy and lactation:
The drug should not be used during pregnancy unless the clinical condition of the woman requires the use of erythromycin. Based on data on the use of oral Erythromycin, it is anticipated that erythromycin may cause birth defects such as cardiovascular defects and pyloric stenosis when administered during pregnancy.
Side effects:
Uncommon: pruritus, erythema, skin irritation, burning sensation, stinging, dry skin, exfoliation of the epidermis. Very rare: hypersensitivity.
Dosage:
Outwardly. Mix both ingredients before use. The surface of the skin on which the preparation will be applied should be thoroughly cleaned and dried. The preparation is applied twice a day using the applicator on the skin of the entire face or other changed places (not only for the lesion itself), until it completely covers the area treated, each time consuming approximately 0.5 ml of the solution. A significant therapeutic effect is usually achieved within 12 weeks. The possibility of bacterial resistance to the preparation should be taken into account. If resistance is found, the preparation should be discontinued for a period of 2 months.
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