Index of drugs

Pain complaints of various origin of light and medium intensity, including: headaches, toothache, muscle aches, joint pain. Ailments associated with colds and flu with fever. Conditions that require long-term use of Acetylsalicylic acid in high doses, such as rheumatoid arthritis (prescribed by a doctor). Myocardial infarction and prophylaxis of myocardial infarction.

1 tabl contains 300 mg of acetylsalicylic acid.

A non-steroidal anti-inflammatory drug. Acetylsalicylic acid is an ester of salicylic acid with analgesic, anti-inflammatory and antipyretic properties. The mechanism of action is the inhibition of prostaglandin synthesis - prostaglandin E₂ (PGE₂), prostaglandins I₂ (PGI₂) and thromboxane A₂ - due to the inhibition of arachidonic acid cyclooxygenase (inhibition of COX-1 and / or COX-2 activity). Acetylsalicylic acid also inhibits platelet aggregation. It is absorbed from the digestive tract in 80-100%. Food does not reduce its bioavailability, but it may extend the absorption time. The analgesic and antipyretic action of acetylsalicylic acid used as a suspension (after dissolving the tablet in water) starts after 30 minutes of application, reaching a maximum after 1-3 hours. After a single dose, it is maintained for 3-6 h. Full anti-inflammatory effect occurs in within 1-4 days of treatment. Acetylsalicylic acid is hydrolyzed in plasma to salicylic acid. T_0,5 is about 2-3 h, and salicylic acid about 6 h. About 1% of the dose of acetylsalicylic acid is excreted in the urine in the unhydrolyzed form, the remaining part is excreted in the urine in the form of salicylic acid and its metabolites.

Hypersensitivity to acetylsalicylic acid or any of the excipients. Hypersensitivity to acetylsalicylic acid occurs in 0.3% of the population, including 20% ​​of patients with bronchial asthma or chronic urticaria. Symptoms of hypersensitivity: urticaria and even shock may occur within 3 hours of taking acetylsalicylic acid. Hypersensitivity to other NSAIDs, with symptoms such as: bronchospasm, rhinitis, shock. Bronchial asthma, chronic respiratory diseases, hay fever or nasal edema, as patients with these conditions may respond to NSAIDs with asthma attacks, limited by swelling of the skin and mucous membrane (angioneurotic edema) or urticaria more often than other patients. Active peptic ulcer of the stomach and / or duodenum and inflammation or bleeding from the gastrointestinal tract (gastrointestinal bleeding or ulcer disease). The pregnancy is a failure of the liver or kidneys. Severe heart failure. Blood coagulation disorders (eg haemophilia, thrombocytopenia) and concomitant treatment with anticoagulants (eg coumarin derivatives, heparin). G-6-PD deficiency. Concurrent treatment with Methotrexate ≥15 mg per week due to myelotoxicity. Children under 16, especially in the course of viral infections, due to the risk of Reye's syndrome. III trimester of pregnancy and breastfeeding.

Use with caution in case of hypersensitivity to NSAIDs and anti-rheumatics or other allergenic substances; during the simultaneous use of anticoagulants; in patients with peptic ulcer or history of gastrointestinal bleeding; in patients with impaired renal function and chronic renal failure; in patients with juvenile rheumatoid arthritis and / or systemic lupus erythematosus and liver failure (increased salicylate toxicity) - liver function should be monitored in these patients; when used with doses of <15 mg / week methotrexate (increased methotrexate toxicity on the bone marrow); in the case of uterine haemorrhage, excessive menstrual bleeding, use of intrauterine contraceptive pads, hypertension and heart failure.It must not be used in patients who are taking oral anti-diabetic medicines from the sulphonylurea group (risk of increased hypoglycaemic effect) and in patients taking anti-gout medicines. Acetylsalicylic acid should be discontinued 5-7 days before the planned surgery, due to the risk of prolonged bleeding time both during and after the procedure. Alcohol should not be consumed during treatment with Acetylsalicylic acid, due to the increased risk of gastrointestinal mucosal damage. In elderly patients, the product should be used at lower doses and at longer intervals due to the increased risk of side effects in this group of patients. Taking the product at the lowest effective dose for the shortest period necessary to relieve symptoms reduces the risk of side effects.

The preparation is contraindicated in the third trimester of pregnancy and breastfeeding. In the first and second trimester of pregnancy, it can only be used if there is a definite necessity. Acetylsalicylic acid easily penetrates through the placental barrier. If you need acetylsalicylic acid in women who have just become pregnant or during the first or second trimester of pregnancy, give the lowest effective dose for as short a period as possible. Inhibition of prostaglandin synthesis may adversely affect the course of pregnancy and / or the development of the embryo and fetus. Data from epidemiological studies indicate an increased risk of miscarriage and the occurrence of heart defects and gastrointestinal defects associated with the use of prostaglandin synthesis inhibitors in the early weeks of pregnancy. Probably the risk of congenital cardiovascular defects increases with the use of higher doses of the drug and with the extension of the therapy period. In newborns whose mothers used acetylsalicylic acid before delivery, abnormal bleeding episodes such as subconjunctival haemorrhages, haematuria, petechiae, subperiosteal hematoma were observed. Increased incidence of intracranial bleeding has been observed in preterm infants born to mothers who used acetylsalicylic acid one week before delivery. In the third trimester of pregnancy, all prostaglandin synthesis inhibitors may affect the fetus on the cardiovascular system (pulmonary hypertension with premature closure of the Botalla ductus arteriosus) and the kidneys (renal failure with oligohydramnios) and in the mothers inhibit uterine contractility and prolong bleeding time (also in newborns) . Cyclooxygenase-inhibiting drugs can cause fertility disturbances in women by affecting ovulation; this effect is transient and disappears after completion of therapy.

During treatment, indigestion, heartburn, feeling of fullness in the epigastrium, nausea, vomiting, lack of appetite, abdominal pain, gastrointestinal bleeding, damage to the gastric mucosa, ulcer disease, perforations; focal liver cell necrosis, tenderness and hepatomegaly (especially in patients with juvenile rheumatoid arthritis, systemic lupus erythematosus, rheumatic fever or a history of liver disease), transient increase in serum transaminases, alkaline phosphatase and bilirubin; tinnitus (usually as a symptom of overdose), impaired hearing, dizziness; proteinuria, presence of leucocytes and erythrocytes in the urine, renal papillary necrosis, interstitial nephritis; heart failure; hypertension; thrombocytopenia, anemia due to gastrointestinal bleeding, haemolytic anemia in patients with G-6-PD deficiency, leukopenia, agranulocytosis, eosinopenia, increased risk of bleeding, prolonged bleeding time, prolonged bleeding time, prolonged prothrombin time; rash, urticaria, angioneurotic edema, bronchospasm, shock.

Orally. Symptomatic treatment without medical advice may be given for no more than 3 days. Analgesic and antipyretic. Adults: 1-2 tabl. every 4 h. The maximum daily dose is 3 g. Youth> 16 years: 2-3 tabl. per day. In inflammatory conditions as indicated by the doctor, usually: in rheumatic fever - 3 tabl. 4 times a day; in rheumatoid arthritis - 2 tabl. 3-4 times a day. Myocardial infarction, prophylaxis of myocardial infarction: 1 / 2-1 tabl. per day. The tablets should be taken with or after a meal with plenty of liquid.The tablet can be dissolved in 1/2 glass of water or milk.