Index of drugs

Pain of various origins of weak to moderate severity, e.g. dysmenorrhoea, headache, teeth, muscles, post-traumatic pain, neuralgia. Fever of various origins. Relief of cold and flu symptoms.

1 tabl powl. contains 400 mg of ibuprofen; drug contains lactose.

The derivative of propionic acid from the NSAID group, has analgesic, antipyretic and anti-inflammatory effects. The mechanism of action is based on inhibition of prostaglandin synthesis. Transiently inhibits platelet aggregation. Ibuprofen is absorbed faster on an empty stomach, slower after a meal. C_max occurs after 1-2 h. Plasma protein binds in 90-99%. It is excreted in the urine in the form of 2 inactive metabolites. T_0,5 is 2 hours.

Hypersensitivity to the components of the preparation. Hypersensitivity to Acetylsalicylic acid and other non-steroidal anti-inflammatory drugs, manifested by bronchial asthma, rhinitis, urticaria. Active or in history of peptic ulcer disease and / or duodenum with perforation or bleeding. Third trimester of pregnancy. Severe heart, liver and kidney failure. Hemorrhagic diathesis. Concomitant use of other NSAIDs, including COX-2 inhibitors.

Caution in patients with: systemic lupus erythematosus, mixed connective tissue disease, gastrointestinal disease, chronic inflammatory bowel disease (ulcerative colitis, Leśniewski and Crohn's disease), hypertension, history of cardiac dysfunction, edema, kidney or liver function. In patients with active or past bronchial asthma and allergic diseases can trigger bronchospasm. Ibuprofen acts as an antiplatelet agent and may prolong bleeding time, therefore caution should be used when administering patients with coagulation disorders and those treated with anticoagulants. Caution use in patients taking other medicines that may increase the risk of stomach and intestinal disorders or bleeding (corticosteroids, anticoagulants). Concomitant long-term intake of analgesics can lead to kidney damage with the risk of renal failure. Ibuprofen may mask the symptoms of infection and fever. Caution should be exercised when combined with ciclosporin, Methotrexate, Digoxin, lithium, probenecid, valproic acid. The drug contains lactose, therefore it should not be used by patients with rare hereditary galactose intolerance, lactase deficiency (Lapp type), malabsorption of glucose-galactose. Not recommended for children with mc. less than 7 kg. Do not use in children under 12 years.

In the third trimester of pregnancy, the preparation is contraindicated. In the I and II trimester of pregnancy, the preparation can be used only in case of extreme necessity. Ibuprofen and its metabolites can penetrate into breast milk in small amounts. In the doses recommended for the above Indications for short-term use do not need to stop the infant from breasts. The use of ibuprofen may impair fertility in women - for women who have difficulty conceiving or are tested for fertility, discontinuation of the preparation should be considered. It is not recommended to give the drug to women planning pregnancy.

Uncommon: dyspepsia, pain and discomfort in the abdomen, heartburn, nausea, dizziness, rash, urticaria, pruritus. Rare: diarrhea, bloating, constipation, vomiting, gastritis, headache, swelling, pruritus. Very rare: ulcerative oral mucositis, exacerbation of colitis, Crohn's disease, tarry stools, bloody vomiting, duodenitis, oesophagitis, depression, insomnia, confusion, mood swings, agitation, drowsiness, irritability and fatigue, convulsions, aseptic meningitis with a fever or coma, tinnitus, decreased urine output, renal failure, renal papillary necrosis, sodium retention, liver dysfunction,especially during long-term use - hepatitis, pancreatitis, jaundice, increased liver enzymes, anemia (hemolytic and aplastic), agranulocytosis, leukopenia, thrombocytopenia (without or purpura), pancytopenia, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria, erythema multiforme, alopecia, exfoliative dermatitis, hypersensitivity to light, face edema, larynx, tongue, dyspnoea, tachycardia, hypotension, shock, acute shock, asthma exacerbation, bronchospasm, hypotension, hypertension, heart failure associated with the use of drugs from the NSAID group in high doses. Gastric and / or duodenal ulcer may occur, gastrointestinal bleeding (which may lead to death) and perforation, especially in the elderly. First symptoms of blood and lymphatic system disorders: fever, sore throat, superficial ulceration of the oral mucosa, flu-like symptoms, fatigue, bleeding (eg bruises, ecchymosis, purpura, nosebleeds). There have been reports of hypersensitivity reactions to ibuprofen: allergic reactions, neutropenia, eosinophilia, hematocrit reduction, hearing loss, and visual disturbances. In patients with autoimmune diseases such as systemic lupus erythematosus, mixed connective tissue disease, ibuprofen users, isolated cases of symptoms of aseptic meningitis have been reported: stiff neck, headache, nausea, vomiting, fever, confusion. In isolated cases, there have been acute hypersensitivity reactions that are manifested by hypotension. The intake of Ibuprofen, especially long-term at high doses (2,400 mg / day) may be associated with a small increase in the risk of arterial blockages (eg myocardial infarction or stroke).

Orally. Adults and children> 12 years: 1 tabl. every 4 hours. During the 24-hour period, no more than 3 tablets should be taken (maximum daily dose of 1200 mg in divided doses).