Treatment of symptoms of mild to moderate osteoarthritis of the knee joints.
Composition:
One 3950 mg sachet contains 1884.0 mg of crystalline Glucosamine sulphate (equivalent to 1500 mg glucosamine sulphate). The drug contains aspartame.
Action:
Glucosamine sulphate is a substrate for the synthesis of proteoglycans that are a part of the articular cartilage substance. The supply of glucosamine sulphate from the outside stimulates the biosynthesis of proteoglycans, which is disturbed in osteoarthritis. Stimulation of proteoglycan synthesis exerts a beneficial effect on cartilage trophism and facilitates the synthesis of chondroitiniar acid, which counteracts cartilage degeneration. After oral administration, glucosamine sulphate is absorbed in 89%. The maximum concentration in the blood reaches after 10-24 h. It does not bind to blood proteins. It is distributed in the liver, kidneys and joint cartilage. T0,5 is 54.8-80.9 h. About 70% is metabolised in the liver. It is excreted in the urine (9.6%), feces (11.3%) and in 80% as CO2 through the respiratory system.
Contraindications:
Hypersensitivity to glucosamine. Phenylketonuria (the drug contains aspartame).
Precautions:
Caution should be exercised in patients with shellfish allergies (glucosamine is obtained from crustaceans). Clinical trials have not been conducted in patients with renal or hepatic impairment; Caution should be exercised in patients with severe renal or hepatic impairment. It must not be used in children and adolescents under 18 years of age, as the safety and efficacy of glucosamine has not been established. The medicine contains sodium (151 mg / dose), therefore caution should be exercised in patients using a controlled sodium diet.
Pregnancy and lactation:
It can be used during pregnancy and breastfeeding only if the benefits of treatment outweigh the potential risks. Do not use the drug during the first trimester of pregnancy.
Side effects:
You may experience discomfort and abdominal pain, constipation, diarrhea, nausea, hypersensitivity reactions (including skin rash with pruritus and erythema).
Dosage:
Orally. Adults: 1 sachet per day. The effectiveness of the drug has been demonstrated for up to 3 months with residual effects visible for 2 months after discontinuation of the drug. Efficacy and safety have also been confirmed in a key clinical trial of the medicine for up to three years. Continuous dosing for over 3 years can not be recommended as the safety of the medicine has not been established beyond 3 years.
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