Index of drugs

Symptomatic treatment in the course of rheumatoid arthritis and osteoarthritis in adult patients.

1 tabl powl. contains 600 mg of ibuprofen.

Hypersensitivity to Ibuprofen, other NSAIDs or to any of the excipients. Past hypersensitivity reactions, such as bronchial asthma, rhinitis or urticaria caused by the administration of salicylates (including acetylsalicylic acid) or other NSAIDs. Peptic ulcer of the stomach and / or duodenum, active or history, perforation or bleeding, also those occurring after administration of NSAIDs. Active or recurrent peptic ulcer or bleeding (two or more episodes of documented ulcer or haemorrhage). Concomitant use of other NSAIDs, including COX-2 inhibitors. Hemorrhagic diathesis. Severe heart failure. Severe hepatic failure. Severe renal failure. Third trimester of pregnancy.

The use of Ibuprofen in the first and second trimester of pregnancy is not recommended. In the third trimester, the use of ibuprofen is contraindicated due to a decrease in uterine contraction (which may lead to delay or prolonged delivery), premature closure of Botalla ductus arteriosus and pulmonary hypertension in the newborn, risk of prolonged bleeding in the mother and child, and edema mother. Ibuprofen and its metabolites can penetrate into human milk in very small amounts (0.0008% of the applied dose). Interruption of feeding is not necessary with short-term use of ibuprofen in doses used to treat pain and fever. The use of ibuprofen may reduce fertility in women and it is not recommended for women who are planning pregnancy. For women who have difficulty conceiving or who are being tested for infertility, discontinuation should be considered.

Common: rash, eczema. Uncommon: urticaria, pruritus, headache, indigestion, abdominal pain, nausea. Rarely: dizziness, insomnia, agitation, irritability, fatigue, diarrhea, bloating, constipation, vomiting, gastritis, edema. Very rare: haematological abnormalities - anemia, leukopenia, thrombocytopenia, pancytopenia, agranulocytosis (first symptoms are fever, sore throat, superficial ulceration of the oral mucosa, flu-like symptoms, fatigue, bleeding, eg bruises, ecchymosis, purpura, nosebleed) ; severe hypersensitivity reactions (eg swelling of the face, tongue and larynx, dyspnoea, tachycardia, hypotension, shock, anaphylactic reaction), exacerbation of asthma and bronchospasm, tarry stools, bloody vomiting, ulcerative oral mucositis, exacerbation of colitis and Cohn's disease , liver dysfunction (especially during long-term use), erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, decreased urine output, renal failure, renal papillary necrosis, increased sodium in the blood (sodium retention) . Isolated cases: aseptic meningitis (mainly in patients with autoimmune disease, e.g. systemic lupus erythematosus and related connective tissue diseases), depression, psychotic reactions, tinnitus. Gastric and / or duodenal ulcer may occur, perforation, gastrointestinal bleeding, sometimes fatal, especially in the elderly. N edtions, hypertension, and heart failure have been reported with NSAIDs. Clinical trials and epidemiological data suggest that intake of ibuprofen, especially long-term at high doses (2,400 mg / day) may be associated with a small increase in the risk of arterial thrombosis (eg myocardial infarction or stroke). Additional side effects may occur during long-term therapy with high doses.

Orally. Adults: 1200-1800 mg / day, in divided doses.For some patients, 600-1200 mg / day is a sufficient dose. In the case of acute pains, a larger dose may be used, leading to pain relief, not exceeding the dose of 2400 mg / day.Special groups of patients. No dose adjustment is necessary for the elderly, as long as renal and hepatic function is normal; otherwise the dose should be selected individually. Do not give to children <12 years.