Pains of various origins of low to moderate severity (headache, including tension pain and migraine, toothache, muscle, joint and bone pain, neuralgia, pain associated with influenza and cold). Fever of various origins (including flu, colds or other infectious diseases). Painful menstruation.
Composition:
1 tabl powl. contains 200 mg or 400 mg ibuprofen.
Action:
A non-steroidal anti-inflammatory drug, a propionic acid derivative. Anti-inflammatory, analgesic and antipyretic. The mechanism of action is based on inhibition of prostaglandin synthesis. Ibuprofen also has the ability to reversibly inhibit platelet aggregation. It is well absorbed from the gastrointestinal tract, Cmax is achieved within 1-2 h after administration. It binds to plasma proteins in about 99%. It is metabolised in the liver to two major inactive metabolites, which in free form or as conjugates are excreted by the kidneys together with ibuprofen unchanged. Renal excretion is rapid and complete. T0,5 is about 2 hours.
Contraindications:
Hypersensitivity to Ibuprofen, any of the excipients and to other NSAIDs. In patients who have experienced a history of allergy in the form of rhinitis, urticaria, edema or asthma after taking Acetylsalicylic acid or other NSAIDs. Active or in history of peptic ulcer of the stomach and / or duodenum, with gastrointestinal perforation or bleeding, also those occurring after the use of NSAIDs. Severe hepatic, renal or cardiac failure. Taking other NSAIDs simultaneously, including COX-2 inhibitors. Third trimester of pregnancy. Bleeding from cerebral vessels or other active bleeding. Hemorrhagic diathesis.
Precautions:
Use with caution in patients with systemic lupus erythematosus or mixed connective tissue disease (risk of developing aseptic meningitis); with chronic intestinal inflammation: ulcerative colitis, Crohn's disease (risk of exacerbation of the disease); with hypertension and / or cardiac dysfunction (risk of renal dysfunction and fluid retention); with impaired renal function (risk of further deterioration in their functioning); immediately after a major surgery; with impaired liver function; with blood coagulation disorders (the drug may prolong the bleeding time); with active or a history of bronchial asthma and allergic diseases (risk of bronchial spasm); in the elderly (increased risk of side effects). Caution is advised when co-administered with anticoagulants (eg warfarin), antiaggregates (eg salicylic acid), corticosteroids and alcohol - an increased risk of gastrointestinal toxicity and bleeding (if co-treatment with ibuprofen and these drugs is needed, treatment should be considered associated with protective drugs e.g. misoprostol or proton pump inhibitors). Concomitant long-term intake of analgesics may lead to kidney damage with the risk of renal failure (resolved nephropathy). Immediate treatment should be discontinued with ibuprofen if bleeding or ulceration of the gastrointestinal tract occurs; skin rash, lesions affecting mucous membranes or any signs of hypersensitivity, visual disturbances. Ibuprofen may mask the symptoms of infection and fever. Do not use this medicine in children under 12 years of age.
Pregnancy and lactation:
Do not administer ibuprofen in the first and second trimester of pregnancy unless clearly necessary (increased risk of miscarriage and heart defects). The preparation is contraindicated in the third trimester of pregnancy (in the fetus there may be: toxic effects on the heart and lungs, including premature closure of the ductus arteriosus and pulmonary hypertension, renal dysfunction, which may lead to renal failure with oligohydramnios, in the mother may inhibit uterine contraction causing delay or prolongation of delivery, in the mother and in the newborn it is possible to prolong the bleeding time and the anti-aggregation effect).Discontinuation of breastfeeding is not necessary during short-term treatment with ibuprofen at doses used to treat pain and fever. Ibuprofen may affect fertility in women by affecting ovulation; this effect is transient and disappears after discontinuation of the preparation.
Side effects:
Uncommon: indigestion, abdominal pain, nausea, headache, urticaria, pruritus. Rare: diarrhea, bloating, constipation, vomiting, gastritis, dizziness, insomnia, agitation, irritability or fatigue. Very rare: exacerbation of colitis and Cohn's disease, peptic ulcer of the stomach and / or duodenum, perforation and gastrointestinal bleeding (sometimes fatal, especially in the elderly), acute renal failure, liver dysfunction, renal papillary necrosis - especially during long-term use (with increased serum urea and edema), blood disorders (anemia, leukopenia, thrombocytopenia, pancytopenia, agranulocytosis), severe skin reactions (erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis), swelling of the face, tongue and larynx, dyspnoea, tachycardia, hypotension (angioneurotic edema, anaphylactic shock), exacerbation of asthma and bronchospasm, palpitations, heart failure, myocardial infarction. Frequency unknown: depression, psychotic reactions, tinnitus, idle meningitis. The occurrence of edema, hypertension and heart failure has been reported with NSAIDs. The intake of ibuprofen especially at high doses (2,400 mg / day) over a long period of time may be associated with a small increase in the risk of arterial blockages (e.g., myocardial infarction or stroke).
Dosage:
Orally. Ad hoc. Adults and children over 12 years: the initial dose is 400 mg, then, if necessary, after 4 hours can be taken 200-400 mg. Do not use a dose of more than 1200 mg ibuprofen per day. Keep a 4 hour interval between doses. Do not use for more than 3 days without a doctor's recommendation. The tablets should be taken with water. People with gastrointestinal complaints are advised to take the medicine during a meal.
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