Index of drugs

Table. 200 mg, 400 mg. acute painful conditions from mild to moderate intensity, eg headache, toothache, backache, muscle and joint pain. Fever in the course of infection of the upper respiratory tract. Painful menstruation without an organic cause.Table. 600 mg. Osteoarthritis, rheumatoid arthritis.

1 tabl powl. contains 200 mg, 400 mg or 600 mg ibuprofen. The preparation contains sucrose and lactose (table 600 mg).

A drug from the group of non-steroidal anti-inflammatory drugs. It exerts anti-inflammatory, analgesic and antipyretic effects by inhibiting prostaglandin cyclooxygenase. Reversibly inhibits platelet aggregation. It is quickly absorbed from the digestive tract. Maximum concentration in plasma occurs within 1-2 h. T_0,5 is about 2 hours. Plasma proteins are approximately 99% bound. 60% of the Ibuprofen dose is excreted in the urine, the rest is eliminated in the faeces. The entire administered dose is removed within 24 hours.

Hypersensitivity to ibuprofen or other components of the preparation. Pre-existing hypersensitivity (symptoms of asthma, urticaria, rhinitis) to Acetylsalicylic acid or other NSAIDs. Conditions with an increased bleeding tendency. Gastrointestinal haemorrhage or history of perforation associated with the use of NSAIDs. Active or recurrent peptic ulcer and / or duodenal ulcer (two or more separate episodes of documented ulceration or bleeding). Cirrhosis. Severe heart failure and severe renal impairment (glomerular filtration <30 ml / min). Third trimester of pregnancy.

The concomitant use of the preparation and NSAIDs, including selective COX-2 inhibitors, should be avoided. Use with caution in elderly patients, due to the greater risk of side effects, including gastrointestinal bleeding and / or perforation and renal, cardiac or hepatic impairment. In patients with a history of gastrointestinal ulceration, especially if there is a complication of haemorrhage or perforation and in elderly patients, caution should be used and treatment should be started with the lowest dose and the combination of corticosteroids (eg misoprostol or proton pump inhibitors) considered. In patients receiving low-dose acetylsalicylic acid or other medicines that increase the risk of gastrointestinal complications, protective formulations should also be considered. The preparation should be discontinued in case of bleeding from the gastrointestinal tract or ulcer and the first symptoms of skin rash, changes on mucous membranes or any other signs of hypersensitivity. Patients with systemic lupus erythematosus, haematological disorders or with coagulation disorders should be carefully monitored during treatment. Patients with asthma must be cautious when using the product. The risk of fluid retention and renal dysfunction should be considered for treatment of patients with mild to moderate heart disease, kidney disease or liver disease, especially if diuretic therapy is concomitantly administered. Caution should be exercised in patients receiving concomitant medications that may increase the risk of ulceration or bleeding, i.e. oral corticosteroids, anticoagulants, e.g. Warfarin, selective serotonin reuptake inhibitors or anti-aggregating agents acetylsalicylic acid. Due to the sucrose content, the preparation should not be used in patients with fructose intolerance, sucrase-isomaltase deficiency or malabsorption of glucose-galactose. Table. 600 mg. Patients with uncontrolled hypertension, congestive heart failure, advanced ischemic heart disease, obstructive artery disease and / or cerebrovascular disease, and patients with risk factors for cardiovascular disease should be treated after careful consideration of the benefit / risk ratio.Due to the lactose content, the preparation should not be used in patients with galactose intolerance, Lapp lactase deficiency or malabsorption of glucose-galactose.

In the I and II trimester, do not use the preparation if it is not absolutely necessary. In the third trimester, the preparation is contraindicated (reduction of uterine contractile function, premature closure of Botalla ductus arteriosus, pulmonary hypertension in the newborn, increased risk of prolonged bleeding in the mother and child, edema in the mother). Ibuprofen and its metabolites can penetrate into breast milk in small amounts. In the doses recommended for the above Indications for short-term use do not need to stop the infant from breasts. Ibuprofen may affect fertility in women by affecting ovulation, hence it is not recommended for women planning pregnancy. This effect is transient and disappears after discontinuation of the preparation.

Common: fatigue, headache; indigestion, diarrhea, constipation, nausea, vomiting, abdominal pain; eczema. Uncommon: haemorrhage, ulceration, ulcerative oral mucositis; urticaria, pruritus, purpura, angioneurotic edema; rhinitis, asthma; insomnia, mild anxiety; blurred vision; hearing impairment. Rare: edema, anaphylactic reactions; heart failure, hypertension, fluid retention; leukopenia, thrombocytopenia; gastritis, haemoptysis, colitis, tarry stools, perforation, flatulence, exacerbation of ulcerative colitis and Crohn's disease; bullous reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme; liver disorders; sterile meningitis; depression, confusion; kidney problems; amblyopic amblyopia. Ibuprofen may prolong the bleeding time by reversibly inhibiting platelet aggregation. Ibuprofen, especially at a high dose when used for a long time, may increase the risk of arterial blockages.

Treatment should be started with the lowest effective dose, so that later it can be adjusted depending on the therapeutic response and potential adverse reactions.Table. 200 mg, 400 mg. Acute pain and fever in the course of upper respiratory tract infections: adults and children over 12 years: 200-400 mg in a single dose or 3-4 times a day, the maximum daily dose is 1200 mg, the interval between two doses should be at least 4 h; children 6-12 years (> 20 kg): 200 mg 1-3 times a day, the interval between two doses should be 6-8 h. Painful menstruation: 400 mg 1-3 times a day if necessary, interval between two doses should be at least 4 hours. Table. 600 mg. Rheumatic diseases: usually 600 mg 3 times a day, the maximum daily dose is 2400 mg, the first dose should be taken on an empty stomach to get a quick reduction in early bladder joint stiffness.
In patients with renal insufficiency, the dose should be reduced.