the product in the database has an inactive status
indications:
Acute headache in migraine (with or without aura). Tension headache. Back pain, teeth, muscles, joints, painful menstruation, neuralgia. Pain in the course of colds and flu.
Composition:
1 tabl powl. contains 684 mg of Ibuprofen lysine salt, equivalent to 400 mg ibuprofen.
Action:
A drug from the group of non-steroidal anti-inflammatory drugs. It has anti-inflammatory, analgesic and antipyretic properties by inhibiting prostaglandin cyclooxygenase. The addition of lysine increases the solubility of ibuprofen in water and accelerates the absorption of the drug from the gastrointestinal tract. After oral administration, the drug is absorbed quickly and completely, reaching a maximum concentration in the blood after about 35 minutes. About 99% is bound to plasma proteins. It is metabolised in the liver to inactive metabolites. T0,5 It is 1.8-3.5 hours. It is excreted in the form of metabolites mainly in the urine (90%) and in a small amount in the bile.
Contraindications:
Hypersensitivity to the preparation ingredients and other NSAIDs. Previous asthma, rhinitis or urticaria - after Acetylsalicylic acid or other NSAIDs. Active or peptic ulcer of the stomach and / or duodenum. Blood coagulation disorders. Third trimester of pregnancy. The preparation is not indicated for use in children up to 12 years of age.
Precautions:
In patients with porphyria, systemic lupus erythematosus, or mixed connective tissue disease, the benefit-risk ratio should be considered before taking the medicine. Particularly cautiously use in patients with gastrointestinal disease, including ulcerative colitis and Crohn's disease; with hypertension and / or cardiac dysfunction; with impaired renal function; with severe hepatic impairment; immediately after major surgery; with bronchial asthma or other allergic reactions currently or in history (taking the preparation may cause bronchospasm); in elderly patients (there is an increased risk of side effects).
Pregnancy and lactation:
Due to the lack of tests, the use of ibuprofen in the first and second trimester of pregnancy is not recommended. In the third trimester, the preparation is contraindicated (it may cause severe fetal dysfunction and in the mother suppress the uterine contraction function). Ibuprofen and its metabolites can penetrate into breast milk in small amounts. In the doses recommended for the above Indications for short-term use do not need to stop the infant from breasts. Ibuprofen may affect fertility in women by affecting ovulation. This effect is transient and disappears after discontinuation of the preparation - the drug is not recommended for women planning pregnancy.
Side effects:
Uncommon: indigestion, abdominal pain, nausea, headache, urticaria, pruritus. Rare: diarrhea, bloating, constipation, vomiting, dizziness, insomnia, agitation, irritability, fatigue, edema. Very rare: peptic ulcer of the stomach and / or duodenum, gastrointestinal bleeding and perforation, oliguria, renal failure, renal papillary necrosis, sodium retention, liver dysfunction, anemia, leukopenia, thrombocytopenia, pancytopenia, agranulocytosis, erythema multiforme, facial edema , tongue and larynx, dyspnoea, tachycardia, hypotension, shock, worsening asthma symptoms, bronchospasm. In individual cases: depression, psychotic reactions, oral noise. In patients with existing autoimmune disorders (systemic lupus erythematosus, mixed connective tissue disease), symptoms of aseptic meningitis were observed in isolated cases: stiff neck, headache, nausea, vomiting, fever, confusion.
Dosage:
Orally. Adults and children over 12 years of age: 1 tab. every 4 hours, up to 3 tables daily (1200 mg ibuprofen / day). Tablets swallow whole (do not chew and do not suck), drink with liquid; can be taken with food.
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