the product in the database has an inactive status
indications:
Treatment of rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, extradural rheumatism (tendinitis, bursitis, and cruciate ligament).
Composition:
1 ampoule of 2 ml contains 100 mg of ketoprofen.
Action:
A non-steroidal anti-inflammatory drug (included in profes - derivatives of arylpropionic acids) with a strong anti-inflammatory, analgesic and antipyretic effect. It inhibits the synthesis of prostaglandins and the release of lysosomal enzymes, has antiradkinin activity and inhibits the migration of macrophages. By increasing capillary permeability and reducing macrophage migration (e.g., synovium, exudate), it has activity in the early vascular and late phase of cellular inflammation. It inhibits platelet aggregation. It is rapidly absorbed after intramuscular administration, reaching a maximum concentration in the blood after about 20-30 minutes. It is 99% bound to plasma proteins, penetrates into fluids, tissues (including synovial fluid, where it reaches a higher concentration than in plasma) and through the placental barrier. Inactivated in the body by conjugation with glucuronic acid and to a small extent by hydroxylation. Excreted in 65-75% as glucuronide and in 1% in unchanged form by the kidneys. T0,5 It is 1.2 h. After 6 h, approximately 50% of the administered dose passes into the urine. In the elderly, slower drug metabolism, prolonged half-life and elimination are observed.
Contraindications:
Hypersensitivity to the drug and other derivatives of phenylcarboxylic acids and in patients reacting with asthma attacks to Acetylsalicylic acid and derivatives. Active or recurrent peptic ulcer disease, duodenum, haemorrhagic diathesis, severe renal or hepatic failure, infectious diseases. Do not use in the third trimester of pregnancy and breast-feeding. In the I and II trimesters of pregnancy, use only in extreme necessity. Children up to 15 years of age Use with caution in patients with history of gastric or duodenal ulcer, hypertension, hepatic or renal impairment, concomitant use of diuretics or anticoagulants from the vitamin K group. on the impairment of the drug psycho-fitness and the possibility of dizziness - do not use on drivers, machine operators. Reduce doses in elderly patients.
Precautions:
Pregnancy and lactation:
Side effects:
Gastrointestinal disorders (gastrointestinal disorders, epigastric pain, nausea, vomiting, diarrhea, constipation), peptic ulcer recurrence, gastric or duodenal ulcer may occur, more rarely - gastrointestinal bleeding, gastrointestinal perforation, headache and dizziness , allergic skin reactions (pruritus, urticaria, rash - exceptionally: Lyell's syndrome, Stevens-Johnson syndrome). People who are allergic to acetylsalicylic acid and derivatives can trigger an asthma attack. Occasionally, it causes a decrease in the number of erythrocytes, leukopenia, and renal failure. It lowers psychomotor efficiency and lengthens the reaction time.
Dosage:
Intramuscularly. Adults: 100-200 mg (1-2 amp) daily, usually in 2 doses for 5-15 days. If necessary, the treatment should be continued using oral forms.
(C)
