Acute and chronic liver disease, including alcoholic liver damage, toxic and drug-induced liver damage and chronic hepatitis. Supportive in the treatment of functional disorders of the liver, bile ducts and cholelithiasis.
Composition:
1 hard capsules contain 300 mg of phospholipids from soybeans. The capsules contain soybean oil.
Action:
The preparation with hepatoprotective effect. The mechanism of action of poly (phosphatidylcholine) (PPC) is mainly the ability to integrate into cell membranes and membranes of cellular organelles, where it replaces endogenous phospholipids, constituting their basic structural and functional element, while displaying a special affinity for liver cells. As a result, it accelerates the elimination of fat deposits from hepatocytes, inhibits fibrosis, normalizes AspT, ALAT and GGTP. PCC prevents and limits the development of liver fibrosis caused by ethyl alcohol and carbon tetrachloride. Increases collagenase activity, which accelerates collagen degradation. PPC in alcoholic liver damage in addition to inhibition of fibrosis processes, accelerates elimination of fat deposits from hepatocytes and normalization of biochemical indicators of liver damage. PCC is absorbed from the gastrointestinal tract in 90%. The maximum concentration in the blood occurs after 6 hours after administration. The highest concentration is achieved in the liver, adipose tissue, and striated muscles. Phospholipids are secreted mainly in the bile. T0,5 is about 30 hours.
Contraindications:
Hypersensitivity to the active substance or to any of the excipients.
Precautions:
Due to the content of soybean oil, do not use in case of known hypersensitivity to peanut or soya (purified soy oil may contain peanut protein).
Pregnancy and lactation:
Due to the lack of clinical data on the use of polyacrylphosphatidylcholine (PPC) during pregnancy, caution should be exercised when prescribing to pregnant women. There are no data on the permeation of phospholipids from soybeans to breast milk.
Orally. Adults: 2 capsules (600 mg) 3 times a day, after 2-3 months of treatment use a maintenance dose of 1 capsule 3 times a day. Children: infants - 1 capsule for 10 kg. (300 mg / 10 kg), children - on average 3-6 capsules per day (900-1800 mg). The maximum daily dose is 1800 mg.Duration of treatment. The drug should be taken for at least 3 months.Way of giving: capsules should be taken during meals. The contents of the capsule can be squeezed out and given to children in a small amount of warm milk or water.
(C)
