Hepatic encephalopathy in the course of chronic liver diseases, such as chronic hepatitis, cirrhosis of the liver.
Composition:
1 sachet (5 g of granules) contains 3 g of L-ornithine L-aspartate. The preparation contains sunset yellow, sodium saccharin, sodium cyclamate, fructose.
Action:
L-ornithine L-aspartate takes part in the two most important processes of ammonia detoxification: urea synthesis and glutamine synthesis. Glutamine is a substance in the form of which ammonia is eliminated from the body in a non-toxic form and is an activator of the urea cycle. After oral administration, L-ornithine L-aspartate is absorbed and immediately disintegrates into ornithine and aspartic acid. T0,5 in the phase of elimination of both amino acids is 0.3-0.4 h. Part of aspartic acid is excreted unchanged in urine.
Contraindications:
Hypersensitivity to the components of the preparation. Renal insufficiency of a significant degree (serum creatinine> 3 mg / 100 ml). Disturbances in the metabolism of amino acids involved in the urea cycle, e.g. due to enzymatic defects. Fructose intolerance.
Precautions:
The preparation contains an orange yellow, which may cause allergic reactions (including symptoms of asthma); This type of allergy is especially common in people who are allergic to acetylsalicylic acid. In diabetic patients it should be taken into account that 1 sachet contains 1.13 g fructose, corresponding to 0.11 bread unit. Prolonged use of the preparation may cause tooth decay. There are no data on the use of the drug in children; before possible use, fructose intolerance should be ruled out.
Pregnancy and lactation:
Avoid using the drug during pregnancy. If the use of a medicine is considered necessary, a potential benefit in relation to the risk should be considered. It is not known whether L-ornithine L-aspartate is excreted in human milk - if the use of the drug during breastfeeding is considered necessary, a potential benefit in relation to the risk should be considered.
Side effects:
Uncommon: nausea, vomiting, stomach ache, bloating, diarrhea. Very rare: limb pain. These side effects are usually transient and do not require discontinuation.
Dosage:
Oral: 1-2 sachets 1-3 times a day. Dissolve the contents of the sachet in a glass of water. Accept during or after a meal.
(C)
