Hepatic encephalopathy in the course of acute and chronic liver diseases (eg steatosis, cirrhosis) and hyperammonaemia.
Composition:
1 ampoule (10 ml) contains 5 g of L-ornithine L-aspartate.
Action:
A preparation supporting the detoxification function of hepatocytes. L-ornithine L-asparagate immediately decomposes into ornithine and asparaginate - amino acids involved in two processes of ammonia detoxification: urea synthesis and glutamine synthesis. T0,5 in the phase of elimination of aspartate and ornithine is 0.3-0.4 h. Part of asparaginium is excreted unchanged in urine.
Contraindications:
Hypersensitivity to L-ornithine L-aspartate or any of the excipients. Renal insufficiency of a significant degree (serum creatinine> 3 mg / 100 ml). Disturbances in the metabolism of amino acids involved in the urea cycle (eg due to enzymatic defect).
Precautions:
When using high doses, the concentration of urea in serum and urine should be monitored. For severe hepatic impairment, the infusion rate should be adjusted individually to avoid gastrointestinal disturbances such as nausea or vomiting.
Pregnancy and lactation:
Avoid using the drug during pregnancy and breastfeeding. If the use is deemed necessary, a potential benefit in relation to the risk should be considered.
Side effects:
Uncommon: nausea. Rare: vomiting. Not known: hypersensitivity, anaphylactic reaction. These side effects are usually transient and do not require discontinuation. They disappear after a dose reduction or infusion rate.
Dosage:
Intravenously. Adults. Mostly up to 20 g (4 amp) daily. In pre-comist states and in a coma up to 40 g (8 amps) per day, depending on the patient's condition. There are no data on the use of the drug in children.Method of administration. Before serving, dissolve the contents of the ampoule in the infusion liquid. The preparation can be administered in all commonly used infusion fluids. No incompatibilities related to dissolution have been observed so far. It is recommended to prepare the solution for infusion immediately before administration. Because of the risk of venous damage, do not dissolve more than 6 amps. in 500 ml of liquid. Fill speed: maximum 5 g (1 amp) / h. Do not administer intra-arterially.