A drug for symptomatic use to relieve pain associated with inflammation or irritation in the course of inflammation of the mouth and throat.
Composition:
1 tabl for sucking contains 5 mg of Chlorhexidine dihydrochloride and 1 mg of Lidocaine hydrochloride. The drug contains sorbitol.
Action:
Local anesthetic and antibacterial for use in diseases of the throat and mouth. Lidocaine hydrochloride is a local anesthetic of the amide group, it acts on the surface without disturbing the nerve impulse conduction velocity at the site of application. Chlorhexidine has antibacterial activity by non-specific association with phospholipids of bacterial cell membranes. It inhibits dehydrogenase and ATPase activity and impairs permeability to potassium, nucleotide and amino acid ions. Bacteriostatic, and in higher concentrations (above 20 mg / l) bactericidal especially to Gram-positive bacteria, yeastsCandida albicansand less on Gram-negative. The particularly sensitive bacteria are:Streptococcus mutans, S.salivarius, Escherichia coli, Selenomonas and anaerobic bacteria. The strains have less sensitivityStreptococcus sanguis, Proteus, Pseudomonas, Klebsiella, Veillonella. Lidocaine is distributed in all tissues, it permeates to o.u.n. and to fetal blood. The blood proteins are 33-66% bound. T0,5 is 1.5-2 h. Lidocaine is metabolised in more than 90% by liver microsomal enzymes, partly to active metabolites. Only 10% of lidocaine is excreted in urine in unchanged form and 7% in bile. Decrease in hepatic blood flow, cirrhosis and other liver diseases may lead to increased plasma concentrations of lidocaine. Impaired renal function may cause the accumulation of metabolites. Chlorhexidine is virtually absorbed from the skin and mucous membranes. While sucking tabl. it is slowly released into the saliva and has antibacterial activity. It can partially penetrate the gastrointestinal tract, where it is poorly absorbed and is metabolized in the liver to a very limited extent. Typically, 90% of the dose that entered the gastrointestinal tract is excreted unchanged in the faeces.
Contraindications:
Hypersensitivity to the components of the drug or other local anesthetics from the group of amides. Do not use this medicine in children under the age of 6 years.
Precautions:
Disinfectants do not sterilize; temporarily reduce the amount of microorganisms in the mouth and throat. It should be limited to cases where it is absolutely necessary to alleviate the pain and irritation (do not suck one plate directly after the other). Avoid using the drug in patients particularly prone to allergies. Due to the menthol content, caution should be exercised when using the drug in children if there are symptoms preceding seizures. If the dose is too high (over 20 tablets per day), there is a risk of excessive loss of sensitivity in the glottis area, resulting in decreased control of the swallowing reflex and an increased risk of aspiration. The drug contains sorbitol - it should not be used in patients with rare hereditary problems of fructose intolerance. The drug does not contain sugar, it can be used in diabetics.
Pregnancy and lactation:
The drug should not be used during pregnancy unless clearly necessary. A decision should be made whether to stop breast-feeding or to continue using the medicine, taking into account the benefits for the baby resulting from breastfeeding and the benefits for the woman resulting from the treatment.
Side effects:
Rarely, allergic reactions to the skin and mucous membrane (rashes, oral mucositis) may occur. Possibility of appearance of taste disorders, feelings of burning on the tongue or anaphylactic reactions. After long-term use of Chlorhexidine, brown discoloration may appear on the teeth (discoloration can be removed).
Dosage:
Orally. Adults: 6-10 tabl. for sucking daily, suck slowly. Children> 6 years: 3-5 tabl. for sucking daily. The drug should be used for 3-4 days, do not use for a long time.If there is no improvement or new symptoms and / or general symptoms (eg fever) appear after this time, the patient's condition should be re-evaluated.
(C)
