Symptomatic treatment (cough and coughing) in the course of inflammatory diseases of the bronchi and lungs. Treatment can not delay the start of antibiotic treatment if necessary.
Composition:
1 ml of syrup contains 2 mg of fenspiride hydrochloride. The preparation contains sucrose, glycerol, methyl and propyl parahydroxybenzoate.
Action:
A drug with anti-inflammatory and bronchial relaxants. These properties are most likely the result of several coexisting mechanisms, such as: antagonistic effect on histamine H-receptors1 and papaverine (or musculotropic) spasmolytic activity; anti-inflammatory activity, which may result from reduced secretion of inflammatory mediators (cytokines, TNF-α, arachidonic acid derivatives, free radicals). After oral administration, fenspiride achieves Cmax within 2.3 ± 2.5 hours. It is excreted mainly by the kidneys. T0,5 is about 12 hours.
Contraindications:
Hypersensitivity to the active substance or to any of the excipients. Children <2 years.
Precautions:
Treatment with fenspiride is not a substitute for antibiotic treatment. The drug contains sucrose - should not be used in patients with rare inherited disorders associated with fructose intolerance, malabsorption of glucose-galactose or sucrase-isomaltase deficiency; in addition, sucrose content (2.5 g / 5 ml) should be taken into consideration in patients with diabetes mellitus; contains glycerol which may cause headache, stomach upset and diarrhea; contains p-hydroxybenzoates that can cause allergic reactions (possible late-type reactions).
Pregnancy and lactation:
Due to the lack of tests, the preparation is not recommended for use during pregnancy and in women of childbearing potential not using an effective method of contraception. Do not use during breast-feeding.
Side effects:
The following may occur: hypersensitivity reactions (erythema, rash, urticaria, Quincke's edema, erythema affecting permanent discoloration), drowsiness, gastrointestinal dysfunction, nausea, epigastric pain. Rare: cardiac acceleration (receding after dose reduction).
Dosage:
Orally. Children> 2 years: 4 mg / kg / day (ie, <10 kg: 10-20 ml daily,> 10 kg: 30-60 ml / day). Adults: 45-90 ml daily. Do not use in children <2 years.Way of giving. The drug should be used at the beginning of meals.
(C)
