Treatment of asthma, bronchospasm and / or reversible airway systolic conditions.
Composition:
1 tabl contains 2 mg or 4 mg of Salbutamol in the form of sulphate.
Action:
Sympathomimetic with selective action on β receptors2, which are mainly located in the bronchi. Β operation2-mimetic is associated with the activation of adenylate cyclase, which catalyzes the conversion of ATP to cyclic AMP. Increased concentration of cAMP leads to relaxation of bronchial smooth muscles. In addition, it is believed that the increased concentration of cAMP inhibits the secretion of mediators of an immediate allergic reaction, especially from mast cells. After oral administration, salbutamol is rapidly absorbed. The maximum serum concentration occurs within approx. 2 hours. T0,5 It is about 5 hours. After a single dose, 76% of the dose is excreted in the urine within 3 days, the majority in the first day, about 4% - with faeces.
Contraindications:
Hypersensitivity to salbutamol or other components of the preparation. Threatening miscarriage.
Precautions:
Due to the risk of excessive sympathetic nervous system excitability, they should be used with caution in patients with cardiovascular disease, especially with ischemic heart disease, cardiac arrhythmias and hypertension. Carefully used in patients with hyperthyroidism, patients with epilepsy, diabetes, and in patients with excessive reaction to sympathomimetic amines. The drug may cause transient changes in metabolism such as increased blood Glucose - in patients with diabetes mellitus may occur. Concomitant use of corticosteroids may increase this effect. In patients with severe or unstable asthma, bronchodilator preparations should not be used as the sole or essential - corticosteroids should be considered orally and / or inhaled (maximum doses). The tablets, due to their lactose content, should not be used in patients with rare hereditary galactose intolerance, Lapp lactase deficiency or malabsorption of glucose-galactose.
Pregnancy and lactation:
During pregnancy, use only if the anticipated benefits to the mother outweigh the potential risk to the fetus. The drug may inhibit the uterine contractile function. The use of salbutamol during labor is allowed only if absolutely necessary. Breastfeeding is not recommended unless the benefit to the mother outweighs the potential risk to the child; however, it is recommended that inhaled salbutamol is recommended in such situations.
Orally. Adults and children over 12 years: dosing usually starts from 2-4 mg 3-4 times a day. Doses should be taken at intervals of not less than 6 h. If necessary, the dose may be increased gradually with caution, but up to a dose of 8 mg 4 times a day. Single doses higher than 4 mg can only be used if there is no response to lower doses. In elderly patients and those who are hypersensitive to sympathomimetic amine, a starting dose of 2 mg up to 4 times a day should be used. The maximum daily dose of salbutamol is 32 mg. Children 6-12 years: the starting dose is usually 2 mg 3-4 times a day. The doses should be taken at intervals of not less than 6 h. If necessary, the dose can be increased gradually, but up to a maximum dose of 6 mg 4 times a day. Use caution when using high doses.
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