the product in the database has an inactive status
indications:
Treatment and prevention of bronchospasm in chronic diseases of the respiratory system: bronchial asthma, chronic obstructive pulmonary disease (chronic bronchitis, emphysema).
Composition:
1 suppository contains 350 mg of theophylline.
Action:
A preparation from the methylxanthine group with diastolic and anti-inflammatory smooth muscle relaxants. It also stimulates the respiratory center in o.u.n. by intensifying its sensitivity to CO2. It inhibits the late phase of the allergic reaction. Theophylline in the form of suppositories is well absorbed into the systemic circulation, 40% bound to plasma proteins. The maximum serum concentration occurs after about 2 hours. Theophylline is metabolized in the liver and about 10% is excreted in the urine in unchanged form.
Contraindications:
Hypersensitivity to the components of the preparation. Active peptic ulcer of the stomach and duodenum. Epilepsy. Do not give to patients with a recent myocardial infarction and tachyarritis.
Precautions:
Carefully used in patients with pulmonary heart, with arrhythmias (in addition to bradyarrhythmias), unstable angina, hypertrophic cardiomyopathy with narrowing of the outflow tract, hypertension, hypoxia, porphyria, history of peptic ulcer disease and chronic lung disease, in acute pulmonary edema, in shock, in fever above 38.5 degrees C over 24 hours, in thyroid disorders, during vaccination and sepsis, in kidney diseases and in patients who stopped smoking during treatment. Blood levels of theophylline should be monitored continuously in patients with circulatory insufficiency (congestive heart failure), alcoholism, liver failure, and viral infections, because theophylline clearance may be reduced in these situations, which may lead to an excessive increase in drug plasma. Other products containing theophylline or xanthine derivatives should not be used at the same time. If aminophylline should be administered concomitantly, theophylline plasma levels should be monitored. Theophylline levels should be monitored in elderly patients (> 60 years) due to slower drug excretion. If a patient receiving theophylline develops nausea and vomiting, the drug should be discontinued and the theophylline concentration in the blood should be determined. Ethyl alcohol and tobacco increase theophylline clearance, so it may be necessary to increase theophylline dosage when using theophylline simultaneously. In patients with a history of epilepsy, alternative therapies are recommended because theophylline may increase the intensity of convulsions.
Pregnancy and lactation:
Theophylline crosses the placental barrier and is therefore not recommended during pregnancy. The safety of the medicine in humans has not been established. Do not use in the first trimester of pregnancy. In the second and third trimester, the drug can only be administered if clearly necessary, when the anticipated benefits to the mother outweigh the potential risk to the fetus. Do not use during breastfeeding, because theophylline is excreted in human milk.
Side effects:
The incidence of adverse reactions was defined as an unknown frequency. Gastrointestinal symptoms: heartburn, nausea, vomiting, epigastric pain, diarrhea, bloody vomiting, exacerbation of existing gastroesophageal reflux due to oesophageal sphincter (aspiration of gastric contents may trigger an attack of nocturnal asthma), gastric irritation. Disorders on the part of the father: dizziness and headaches, anxiety, insomnia, hyperactivity, irritability, increased reflexes, muscle tremors, convulsions (even life-threatening). Cardiovascular disorders: palpitations, tachycardia, pressure drops, supraventricular arrhythmia, circulatory failure, redness of the face. Other symptoms: alopecia, increased diuresis, hypersensitivity reactions, pruritus, rash, hyperglycaemia, increased breathing, hyperuricemia, changes in electrolytes, hypokalaemia, hyperglycaemia, increase in serum Calcium and creatinine.
Dosage:
Rectally. Adults: 1 suppository (350 mg) 2 times a day (morning and evening, every 12 hours). The daily dose (person weighing 50-70 kg) is 11-13 mg / kg.
(C)
