1 vial (10 ml) contains or 800 IU of high-purity pork insulin.
Action:
A preparation of high-quality pig insulin with intermediate duration of action. Insulin reduces blood Glucose, increases Glucose transport into cells and enhances glycogen synthesis in muscle tissue and liver, reduces glycogenolysis and gluconeogenesis. It inhibits lipolysis of fats and stimulates the synthesis of fatty acids, reducing the formation of ketone bodies. The hormone also stimulates the synthesis of proteins and inhibits their breakdown in muscles and other tissues. Increases lipogenesis in the liver and adipose tissue, inhibits lipolysis, increases amino acid uptake and protein synthesis. The beginning of the preparation activity occurs after 2 h, the maximum effect - between 6 and 12 h, the total duration of action is about 24 h.
Contraindications:
Hypersensitivity to pork insulin or to any of the ingredients. Hypoglycemia.
Precautions:
In patients with renal and / or hepatic failure, pituitary and adrenal insufficiency, the need for insulin may be reduced. A change to another type of insulin or insulin of another origin should be under strict medical supervision and may require a change in dosage. Particular caution should be exercised when using the preparation in patients who plan to travel abroad; changing the time zone and diet may result in a different need for insulin.
Pregnancy and lactation:
The preparation can be used during pregnancy. The insulin requirement usually decreases in the first trimester and gradually increases during the second and third trimesters of pregnancy, decreases at the moment of delivery, after delivery it quickly returns to pre-pregnancy value. There is no restriction on the use of the product during breastfeeding, however dose adjustment may be necessary.
Side effects:
Most often: hypoglycaemia. The site of insulin administration may include: redness, swelling, itching, pain, hematoma; Occasional: lipodystrophy. Rare: diabetic neuropathy, refraction disorders, diabetic retinopathy, urticaria, rash. Very rare: anaphylactic reactions.
Dosage:
Individually, according to the need for insulin. The preparation can be used alone or simultaneously with fast-acting insulins. In intensive insulin therapy, the suspension can be used as basal insulin (evening and / or morning injections) with fast-acting insulins administered with meals. In children, normoglycemia should be sought, the most appropriate is functional insulin therapy. In patients with renal and (or) hepatic insufficiency, the insulin dose should be reduced accordingly. Elderly patients should not seek normoglycemia; An algorithm of 2 insulin injections is recommended, maintaining a blood glucose below the kidney threshold is often sufficient. Patients with obesity may require increased insulin doses. The preparation is usually given subcutaneously. The preparation can be mixed with Insulinum Maxirapid WO-S alto depuratum TZF or Insulinum Solutio Neutralis WO-S alto depuratum TZF. The preparation is given on the arm or in the front part of the thigh, if necessary, it can be given in the abdominal region or buttock area. The injection site should be changed, the Next injection site should be at least 1-2 cm from the previous injection site.
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