Prevention of pulmonary complications in patients during intensive care after surgery.
Composition:
1 ampoule of 2 ml contains 15 mg ambroxol.
Action:
An expectorant and fluidizing airway secretion. It reduces the viscosity of bronchial secretion and increases its quantity, improves ciliary transport of respiratory epithelium. Increases and accelerates the production of surfactant in the alveoli. T0,5 is about 9 hours. In more than 90% it is excreted by the kidneys in the form of metabolites. It penetrates the blood-brain barrier, the placental barrier and into breast milk.
Contraindications:
Hypersensitivity to Ambroxol or other components of the preparation.
Precautions:
Use cautiously in patients with weakened cough reflexes or disorders of ciliary purification of the bronchi, peptic ulcer of the stomach or duodenum, with impaired renal function or severe liver disease. In patients with bronchial asthma, ambroxol may initially cough.
Pregnancy and lactation:
Ambroxol passes through the placental barrier. Animal studies do not indicate harmful effects with respect to pregnancy, embryonal / fetal development, parturition or postnatal development. Based on the extensive clinical experience in pregnant women after the 28th week of pregnancy, no adverse effects on the health of the fetus have been demonstrated. Despite this, ordinary precautions should be taken when using the drug in pregnant women. Especially in the first trimester of pregnancy, use is not recommended. Ambroxol is excreted in human milk. Although this should not be harmful to newborns, it is not recommended for women who are breastfeeding.
Side effects:
Frequency unknown: nausea, vomiting, diarrhea, indigestion, abdominal pain; anaphylactic reactions (including anaphylactic shock), angioneurotic edema, rash, urticaria, pruritus and other hypersensitivity reactions.
Dosage:
Adults: 2-3 times daily 15 mg / dose intravenously, intramuscularly or subcutaneously; in severe cases 30 mg / dose 2-3 times a day. Children: an average dose of 1.2-1.6 mg / kg m / day in divided doses; children over 5 years: 15 mg / dose 2 or 3 times a day; children 2-5 years: 7.5 mg / dose 3 times a day; children under 2 years: 7.5 mg / dose 2 times a day. Infuse into a vein in saline, Ringer's solution or 5% glucose. With concomitant renal failure, the daily dose should be reduced depending on the creatinine concentration or prolonged intervals between doses. It is beneficial to take an increased amount of fluids during treatment.
(C)
