Acute and chronic respiratory diseases associated with difficult expectoration of viscous secretions: cystic fibrosis, acute and chronic bronchitis, bronchial asthma with coughing disorders, nasopharyngeal inflammation, rhinosinusitis, laryngitis, bronchiectasis. Supportive in respiratory rehabilitation in the pre- and post-operative period.
Composition:
1 tabl contains 30 mg Ambroxol hydrochloride.
Action:
An expectorant with a mucolytic effect. By acting on type II pneumocytes and Clary cells, it stimulates the secretion of follicular and bronchial surfactant. It increases the activity of the ciliary apparatus and reduces the viscosity and amount of mucus. They are quickly and completely absorbed from the gastrointestinal tract reaching the maximum concentration after 2 hours from the time of administration. It easily penetrates tissues. It is 90% bound to plasma proteins. T0,5 is 10-12 h. Ambroxol is metabolised in the liver and excreted by the kidneys in the form of glucuronides. It passes through the blood-brain barrier, through the placenta and into breast milk.
Contraindications:
Hypersensitivity to the components of the preparation.
Precautions:
Particularly cautiously use in cases of peptic ulcer of the stomach and duodenum and in patients with impaired renal function or severe liver failure (the dose should be reduced or prolonged intervals between successive doses). Use cautiously in patients with weakened cough reflexes or impaired ciliary epithelial function of the airways due to the possibility of secretion. The preparation used in patients with bronchial asthma may exacerbate the cough and cause excessive expectoration.
Pregnancy and lactation:
The product can be used during pregnancy and breastfeeding only if clearly necessary.
Side effects:
Sometimes: disorders on the part of the digestive tract (nausea, vomiting, constipation). Rare: hypersensitivity reactions (swelling of the face, skin changes, shortness of breath, fever, chills). There may also be: weakness, headache, increased salivation, runny nose, difficulty urinating.
Dosage:
Orally. Adults: 1 tabl. 3 times a day for 2-3 days, then 1 tabl. 2 times a day. Children from 7 years: 1/2 tabl. 2 times a day.