Secretolytic treatment of acute and chronic lung diseases and bronchitis associated with mucus secretion and transport disorders, in adults, adolescents and children over the age of 6 years. Children under 6 years of age should be given Ambroxol in the form of a syrup or a drop.
Composition:
1 tabl contains 30 mg ambroxol hydrochloride.
Action:
The drug works secretolitically and secretomotorically. Ambroxol is the active metabolite of bromohexine. It increases the amount of serous bronchial secretion and stimulates the secretion and transport of surfactant in the alveoli, which improves the transport of mucus. After oral administration, they are quickly and completely absorbed from the gastrointestinal tract, the maximum concentration in the blood reaches after about 0.5-3 h. T0,5 is 7-12 h. In about 90% it is associated with plasma proteins. Metabolized in the liver. Excreted in 90% with urine in the form of metabolites.
Contraindications:
Hypersensitivity to the active substance or to any of the excipients. Do not use in children under the age of 6 years.
Precautions:
Caution should be exercised in patients with impaired renal function, severe liver disease, gastric and duodenal ulcer disease, and in patients with impaired ciliary purification of the bronchi and high secretion (eg in a rare set of immobile cilia). Very rare cases of severe skin lesions have been observed during treatment with Stevens-Johnson syndrome and toxic epidermal necrolysis, which may cause flu-like symptoms in the early stages of the disease (fever, generalized body pain, rhinitis, cough and sore throat); if new skin or mucosal lesions appear for caution, the drug should be discontinued. In patients with bronchial asthma, ambroxol may initially cough. Do not use the preparation immediately before bedtime.
Pregnancy and lactation:
Caution should be exercised when using the drug during pregnancy. It is not recommended during the first trimester of pregnancy and during breast-feeding.
Side effects:
Common: nausea. Uncommon: vomiting, diarrhea, indigestion and abdominal pain. Rare: rash, urticaria. Very rare: severe skin reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis. Not known: anaphylactic reactions including anaphylactic shock, angioneurotic edema, pruritus and other hypersensitivity reactions. The risk / benefit ratio should be considered in patients with gastric or duodenal ulceration.
Dosage:
Orally. Adults and adolescents> 12 years: 1 tabl. (30 mg) 3 times a day for the first 2-3 days, then 1 tablet. (30 mg) twice daily; if necessary, adults may be increased to 60 mg twice daily. Children 6-12 years: 1/2 tabl. (15 mg) 2-3 times a day. Do not use in children <6 years. Do not use the drug for more than 4-5 days without consulting your doctor.Way of giving. Table. best swallowed whole, after meals, with a sufficient amount of liquid.
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