5 ml of syrup contains 4 mg of butamirate citrate. The preparation contains aspartame, benzoic acid, methyl parahydroxybenzoate and liquid maltitol.
Action:
Non-opioid antitussive drug with central effect. It reduces the frequency and intensity of coughing, inhibiting the cough reflex at the level of the medulla. In addition to the antitussive effect, butamirate slightly relaxes the bronchial muscle. After oral administration, it is absorbed quickly. It is metabolized by hydrolysis to 2 metabolites (2-phenylbutyric acid and diethylaminoethoxyethanol), which also have antitussive activity. Butamirate and its metabolites reach their maximum concentration in the blood after about 1.5 hours after administration. The drug is approximately 95% bound to plasma proteins. T0,5 2-phenylbutyric acid is 21 h and diethylaminoethoxyethanol is 5 h. Metabolites are excreted in the urine in the form of glucuronide conjugate.
Contraindications:
Hypersensitivity to the components of the preparation. Phenylketonuria.
Precautions:
It should not be used in patients with symptoms of severe respiratory depression. Due to the content of benzoic acid and methyl parahydroxybenzoate, the drug may cause allergic reactions (possible late-type reactions). Due to the content of aspartame, the preparation may be harmful for patients with phenylketonuria (5 ml of syrup contains 12.5 mg of aspartame). In addition, the drug contains liquid maltitol, therefore it should not be used in patients with rare hereditary fructose intolerance. The preparation may have a slight laxative effect.
Pregnancy and lactation:
It is not recommended during the first trimester of pregnancy. In the second and third trimester of pregnancy and during breast-feeding, the drug can only be used if necessary.
Side effects:
Uncommon: rash, nausea, diarrhea, dizziness. Symptoms usually disappear during treatment and rarely require a dose reduction; if the described allergic reactions or gastrointestinal disorders do not disappear after the dose reduction, the treatment should be discontinued.
Dosage:
Orally. Adults: 12 mg (3 teaspoons) 4 times a day. Children over 12 years: 12 mg (3 teaspoons) 3 times a day. Children 6-12 years: 8 mg (2 teaspoons) 3 times a day. Children 2-6 years: 4 mg (1 teaspoon) 3 times a day. The drug should be taken before meals.
(C)
