The drug with antitussive effect. Dextromethorphan has an inhibitory effect on the cough center within o.u.n, and its potency is comparable to the equivalent codeine dose. Suppresses cough of various origins, reduces its severity and frequency. In therapeutic doses, it does not inhibit ciliary activity. Quickly and completely absorbed from the gastrointestinal tract. The antitussive activity starts after 10-30 min and persists in adults for 4-6 h and in children by half longer. It is extensively metabolised in the liver. It is believed that metabolites have a significant share in antitussive activity. There are large individual differences in the metabolism of dextromethorphan. It is excreted in the urine, mainly in the form of metabolites.
Contraindications:
Hypersensitivity to dextromethorphan or to any of the excipients. Bronchial asthma and inflammation of the lower respiratory tract. Respiratory failure or risk of its occurrence. Cough with expectoration. Severe hepatic failure. Do not use while taking MAO inhibitors and for 14 days after discontinuation. Breastfeeding period. Children aged <6 years.
Precautions:
Especially careful use in patients with impaired liver function. Due to the risk of overdose, do not use with other medicines containing dextromethorphan. You should not drink alcohol during treatment. Due to the lactose content, do not use the preparation in patients with hereditary galactose intolerance, Lapp lactase deficiency and malabsorption of glucose-galactose.
Pregnancy and lactation:
During pregnancy, use only in cases where the benefit for the mother outweighs the potential risk to the fetus. Do not use during breast-feeding.
Side effects:
The following may occur: nausea, vomiting, stomach ache, constipation, dizziness, drowsiness, hypersensitivity reactions (rash, urticaria, angioneurotic edema, bronchospasm).
Dosage:
Orally. Adults and children> 12 years: 2 tablets every 6-8 h (do not exceed the 120 mg / day). Children 6-12 years: 1 tabl. every 6-8 h (do not exceed 60 mg / day). In the elderly, no dosage adjustment is necessary.
(C)
