Supportingly in acute and chronic lung and bronchial diseases with mucus secretion disturbance and impediments to its transport, ie: acute or chronic bronchitis or bronchitis, bronchial asthma, emphysema, cystic fibrosis.
Drug with secretolytic and secretomotor action (active metabolite of bromohexine). It stimulates type II lung cells and Clary cells in the bronchioles to produce the surfactant. It reduces the viscosity of the secretion and stimulates the activity of the epithelial epithelium, accelerating the transport of mucus. Facilitates coughing and relieves cough. Quickly and almost completely absorbed from the gastrointestinal tract, reaching Cmax during 0.5-3 h. About 30% of the orally administered dose is eliminated as a result of the first pass through the liver. It is excreted in the urine as metabolites. T0,5 is 7-10 hours.
Contraindications:
Hypersensitivity to ambroxol or to any of the excipients. Children aged <6 years.
Precautions:
Particularly caution should be used in patients with: renal or hepatic impairment (in severe renal failure the potential for accumulation of ambroxol metabolites should be considered); with peptic ulcer disease and / or duodenal ulcer; with impaired transport of mucus in the bronchi. In patients with bronchial asthma, ambroxol may initially cough. If changes occur in the skin or mucous membranes, Ambroxol should be discontinued. Due to the lactose content, do not use the preparation in patients with hereditary galactose intolerance, Lapp lactase deficiency and malabsorption of glucose-galactose.
Pregnancy and lactation:
During pregnancy (especially in the first trimester) and breastfeeding, use only after careful assessment of the benefit / risk ratio.
Orally. Adults and children> 12 years: 30 mg (1 tablet) 3 times daily for 2-3 days, then 30 mg twice daily. Children 6-12 years: 15 mg (1/2 tabl) 2-3 times a day. In patients with impaired renal function or severe liver disease, dose intervals should be increased or lower doses should be used. The preparation should be taken after meals, with a sufficient amount of liquid, do not be used immediately before bedtime.
(C)
