The drug is used to remove the symptoms associated with hyperacidity of gastric juice: heartburn, indigestion.
Composition:
1 tabl powl. contains 10 mg of famotidine.
Action:
A competitive antagonist of the histamine H receptor2. After a dose of 20 mg, it inhibits nocturnal secretion of up to 90% o. It inhibits the basic and stimulated secretion of hydrochloric acid and pepsin. Hypergastrinemia which develops after prolonged use of Famotidine disappears after its discontinuation. Famotidine is rapidly absorbed from the gastrointestinal tract, reaching a maximum concentration in the blood within 2-3 hours. In 15-20% it is associated with proteins. The bioavailability of the drug after oral administration is 40-45%. Food and antacids do not affect the absorption of the drug. T0,5 in the blood is about 3 h, in patients with creatinine clearance below 10 ml / min can be extended up to 20 h. Famotidine is excreted in the urine in an unmetabolized form. It penetrates into breast milk.
Contraindications:
Hypersensitivity to famotidine or other components of the preparation. Hypersensitivity to other drugs from the group of H receptor antagonists2 in the interview. Do not use in children under the age of 16 years.
Precautions:
Use with caution in case of peptic ulcer of the stomach or duodenum, hepatic or renal failure and if the medication is used in connection with co-morbid diseases.
Pregnancy and lactation:
Use during pregnancy is not recommended. The drug can be used during pregnancy only if there is a definite necessity. Stop using the product during breastfeeding or stop breastfeeding.
Side effects:
Uncommon: fatigue, transient psychiatric disorders (ie depression, confusion, confusion, anxiety, agitation, hallucinations); nausea, vomiting, discomfort or pain in the abdominal cavity, loss of appetite, dry mouth; increase in liver enzymes, cholestatic jaundice; rash, pruritus, urticaria; anaphylaxis, angioneurotic edema; joint and muscle pain, muscle cramps. Rare: headaches, dizziness; constipation, diarrhea. Very rare: toxic epidermal necrolysis; atrioventricular block; gynecomastia (disappears after discontinuation of the drug). Rare cases of leukopenia, pancytopenia, thrombocytopenia, agranulocytosis and exacerbation of existing liver disease have been observed, however causality was not confirmed.
Dosage:
Orally. Adults and children over the age of 16: 1 tabl. (10 mg) once a day if you get symptoms of heartburn or indigestion. If the symptoms last longer than 1 h or recur after taking the drug, you can take the Next tablet. Do not use more than 2 tables. per day. If the symptoms persist for more than 2 weeks, the use should be considered.Way of giving. Table. it should be swallowed whole with a small amount of water.
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