Constipation. Prevention and treatment of hepatic encephalopathy.
Composition:
5 ml of syrup contains 2.5 g of liquid lactulose.
Action:
The product contains a synthetic disaccharide (lactulose), which is slightly absorbed from the gastrointestinal tract. Lactulose is broken down in the colon (mainly by bacteria from the familyLactobacillus and Bacteroides) to lactic, formic and acetic acid together with carbon dioxide. Acids reduce pH in the colon from 7 to 55,5.5 and have a local osmotic effect, causing water retention in the large intestine. As a result, the content of the large intestine relaxes and stimulates intestinal peristalsis. In addition, acidification of the contents of the large intestine causes the transformation of ammonia into an ammonium ion that is not absorbed from the intestine into the bloodstream and is excreted in the faeces. The consequence of this is a reduction in the concentration of ammonia in the blood, which is important in patients with hepatic encephalopathy. Lactulose is slightly absorbed (up to 3% of the dose) from the digestive tract. It is excreted in the urine within 24 hours. Laxative effects are observed 24-48 hours after administration of the drug.
Contraindications:
Hypersensitivity to the components of the preparation. Bowel obstruction.
Precautions:
Due to the lactose and galactose content, the preparation should not be used in patients with galactose intolerance, Lapp lactase deficiency or malabsorption of glucose-galactose.
Pregnancy and lactation:
The product should be used with caution during pregnancy and during breastfeeding.
Side effects:
Abdominal pain with bloating and cramps may occur. Long-term use or high doses may result in diarrhea with excessive water loss and increased sodium in the blood.
Dosage:
Orally.Constipation.Adults: starting dose - 45 ml once a day before breakfast or 15 ml three times a day before meals, for 3 days; Maintenance dose - 15 ml of fasting syrup. Children over 3 years: initial dose - 5-15 ml per day, then the dose can be gradually increased every 3 days to get the proper bowel movements. Children under 3 years: initial dose - 5 ml per day, then the dose can be increased every 3 days to get the proper bowel movements. Infants: the initial dose - 2.5 ml per day, then the dose can be gradually increased every 3 days to get the proper bowel movements.Hepatic encephalopathy. Adults: 120-180 ml daily in 3-4 divided doses. Large doses of the preparation used in hepatic encephalopathy may cause diarrhea, therefore the dose should be adjusted so that the number of loose stools is not greater than 2-3 per day. If the initial dose causes nausea, it should be reduced. The preparation can be administered with water, juice or milk.
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