the product in the database has an inactive status
indications:
Symptoms of the lower urinary tract associated with benign prostatic hyperplasia.
Composition:
One extended-release capsule contains 0.4 mg Tamsulosin hydrochloride.
Action:
Selective and competitive antagonist of postsynaptic α-adrenergic receptors1. Tamsulosin relaxes the smooth muscles of the prostate and urethra, thus increasing the maximum urinary flow rate. It clears the way of urinary outflow, reducing symptoms of bladder irritation. The reduction in symptoms from bladder filling and emptying persists during long-term treatment. Tamsulosin is rapidly absorbed from the digestive tract, the bioavailability is almost 100%, the food reduces the absorption of the drug. After taking a single dose of tamsulosin (after a meal) the maximum concentration in the blood occurs after about 6 hours. The state of balance is reached by the fifth day after repeated administration of the drug. Tamsulosin is approximately 99% bound to plasma proteins. It is metabolized in the liver and excreted mainly in the urine in the form of metabolites, approx. 9% of the administered dose is excreted in the urine in unchanged form. T0,5 after a single intake of the preparation after a meal it is about 10 hours, in the state of equilibrium about 13 hours.
Contraindications:
Hypersensitivity to the components of the preparation. Angioneurotic edema related to previous tamsulosin use. Orthostatic hypotension. Severe hepatic failure.
Precautions:
Due to the lack of clinical trials, caution should be used in patients with severe renal impairment (creatinine clearance <10 ml / min). It is not recommended to start treatment with tamsulosin in patients who are scheduled to undergo cataract surgery (risk of intraoperative flaccid iris syndrome - IFIS - during cataract surgery).
Pregnancy and lactation:
Not applicable - preparation intended for use in men.
Orally. 1 capsule a day, take after breakfast or after the first meal. The capsule should be swallowed whole with a glass of water, taken in a sitting or standing position.
(C)
