In dentistry - local anesthesia (ascites, archaea, cord) for procedures (single and multiple extractions); conservative dentistry, periodontics, dental prosthetics, some maxillofacial surgery procedures.
Composition:
1 ml of Citocartin 100 contains 40 mg of articaine hydrochloride and 10 μg of L-adrenaline (adrenaline 1: 100,000). 1 ml of Citocartin 200 solution contains 40 mg of articaine hydrochloride and 5 μg of L-adrenaline (adrenaline 1: 200,000). The cartridges contain 1.7 ml of solution.
Action:
Locally anesthetic agent from the group of amide derivatives. It causes reversible suppression of nerve fibers by blocking the sodium potassium pump and inhibition of cell membrane permeability for ions. Articaine is more hydrophilic than Lidocaine, diffuses well into the bone (dissociation constant close to the physiological pH), due to the greater adhesiveness to the protein components of cell membranes is more effective and works longer. The intensity and quality of anesthesia depends on the thickness of anesthetized nerve fibers: the thicker - the slower it occurs and the sooner the analgesic effect subsides. The addition of vasodilators prolongs the action of the local anesthetic, reduces and releases the absorption of local anesthetic into the blood, reduces its concentration in the blood and reduces the risk of toxic symptoms; locally improves hemostasis; it may cause sympathomimetic effects (stronger at β receptors and weaker at α). Onset of action: 1-3 min from injection; average operating time 45-75 min. The medicine's action manifests itself in: shrinking the vessels, relieving the sensation of pain, abolishing the feeling of cold, warmth, touch and pressure. Absorbed articaine is about 94% bound to plasma proteins, it is metabolised by plasma cholinesterase. T0,5 is about 25 min. Metabolites are excreted in the urine.
Contraindications:
Hypersensitivity to topical amide local anesthetics or other ingredients, children under 4 years of age Do not use in patients with cardiomyopathy, advanced atherosclerotic changes in the arteries, hypertension, ischemic changes, headaches, hyperthyroidism, nephropathy, diabetes mellitus, glaucoma. Do not give intravascularly.
Precautions:
Before use, the patient's circulatory system should be evaluated. An aspiration test should be performed and the drug should be administered after a minimum of 10 seconds of observation; when administered in well-vascularized places wait at least 2 minutes for the aspiration test and the initial dose; carefully monitor the patient. The drug is used in conditions of access to oxygen and equipment and anti-shock medicines and to conduct resuscitation.
Pregnancy and lactation:
Do not use during pregnancy and breastfeeding.
Side effects:
May cause a severe allergic reaction or anaphylactic shock. A relative or absolute overdose may cause agitation, excitement, confusion, dizziness, headache or throat, nausea, vomiting, photophobia, mydriasis, tremor, trismus, seizures, apnea, coma. After the administration of toxic doses or in the serum of high concentrations, hypotension, tachycardia, bradycardia, loss of consciousness may occur. At an adrenaline dose of 5-50 μg / 60 kg m.c. the β effect prevails1-mimetic (tachycardia, hypertension), at higher doses - α-mimetic effect: vasoconstriction, hypertension, tachycardia, arrhythmias. Vascular hypertension may occur after intravascular administration. In patients with risk factors for adrenaline (hypertension, coronary heart disease, hyperthyroidism, taking MAO inhibitors), do not administer more than 2 syringes containing a 1: 100,000 adrenaline solution. Very rarely hypersensitivity reactions to the sodium metabisulfite used in the preparation may occur (topical - skin rashes, urticaria, pruritus or general: bronchial spasm, laryngeal edema, apnea, cardiorespiratory failure).
Dosage:
Adults: simple tooth extraction without inflammation - about 1.7 ml Citocartin 100 or Citocartin 200; multiple extractions - 1.7 ml / each tooth, you should try to limit the injection; you can add 1.7 ml atrial; Routine injection into the mandibular aperture is not recommended unless complete anesthesia has been achieved. Prosthetic studies - 0.5-1.7 ml / each tooth depending on the complexity of the procedure. Children - do not exceed the dose of 7 mg / kg m.c. articaine.
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