Anesthesiology and ENT: for lubrication directly before using tracheal and trachethomic tubes, gastric probes, probes, for surface anesthesia of the nasal mucous membrane, nasopharyngeal cavity prior to colonoscopy, nasal polyps surgery, removal of hypertrophy pharyngeal tonsil as initial anesthesia for intubation of conscious persons.Urology: for anesthesia of the urethra before the procedure (catheterisation of the urinary bladder, cystoscopy, crushing of the bladder stones, electrocautery of the bladder papilloma, dilatation of the urethral stenosis) and for covering the surface of tools (catheters, cystoscopes).
Composition:
1 g of gel contains 20 mg Lidocaine hydrochloride.
Action:
Locally anesthetic agent from the short-acting amide derivatives. It causes reversible suppression of nerve fibers by blocking the sodium potassium pump and inhibition of cell membrane permeability for ions. The conductivity in the thin nerve fibers, without the myelin sheath (eg fibers that conduct the sensation of pain and touch) can be inhibited by low concentrations of Lidocaine, the blockage of nerves in the myelin sheath requires higher concentrations. The onset of action on mucosal administration occurs after approx. 2-3 minutes, it lasts approx. 30-60 min. Regardless of the route of administration, lidocaine is distributed in all tissues, crosses the blood-brain barrier and the placental barrier. The degree of binding to proteins is 33-66%. The volume of distribution is 1.7 l / kg. The drug is metabolized in 90% by microsomal enzymes in the liver, partly to active metabolites.
Contraindications:
Hypersensitivity to local anesthetics. Relative contraindications are: shock, atrio-ventricular conduction block IIst. and IIIst., myasthenia gravis, severe liver damage. Carefully use in patients treated with tricyclic antidepressants and MAO inhibitors.
Precautions:
Pregnancy and lactation:
The drug can be used during pregnancy after considering the benefits and risks associated with its use. Caution should be exercised when using the drug in breast-feeding women.
Side effects:
Topical: sporadic, it may cause allergic reactions, rarely - anaphylactic shock. Symptoms associated with general action depend on the concentration of the drug in the blood, which is the resultant: administered dose, place of administration (the drug quickly absorbed from the mucous membranes, well-supplied places, eg crotch areas), local blood flow, body weight and general condition of the patient, liver function and hepatic flow, the age of the patient and accompanying diseases. In the case of absolute overdose (administration of a dose too high in relation to the patient's body weight) or relative overdose (the drug quickly reaches high levels in the blood with rapid absorption), there are: dysgeusia, tongue numbness, headache and dizziness, ringing in the ears, anxiety (at a concentration of lignocaine in the blood about 4-5 μg / ml), visual sensations, agitation (at a concentration of about 6-7 μg / ml), increased muscle tone, muscular tremors (at a concentration of about 7-8 μg / ml), loss of consciousness and generalized seizures (at a concentration of approximately 10 μg / ml), coma (at a concentration of approximately 15 μg / ml), respiratory arrest (at a concentration of approximately 20 μg / ml), severe CNS depression (at concentrations above 20 μg / ml). There may be a significant drop in blood pressure, conductive disorders (intracardiac blocks), cardiac arrest.
Dosage:
Topically for anesthesia of the mucous membranes, directly on the mucous membrane or on the surface of the medical instrument. Do not exceed the dose of lignocaine 3 mg / kg m.c. The type A packaging is provided with an ophthalmic cannula, U-type packaging - with a urological cannula.
(C)
