Superficial anesthesia of the mucous membranes and skin (before injection, in dental procedures, in the extraction of loose teeth, in prosthetics, among others, to reduce the gag reflex when taking impressions).
Composition:
1 g of gel contains 50 mg of Lidocaine hydrochloride. 1 cm of squeezed gel contains about 26 mg lidocaine hydrochloride.
Action:
Locally anesthetic agent from the short-acting amide derivatives, in the form of a homogeneous, opaque, fruit-flavored gel. On resorbable surfaces (mucous membranes) it causes reversible suppression of the nerve fibers by blocking the sodium potassium pump and inhibition of cell membrane permeability to ions. The conductivity in the thin nerve fibers, without the myelin sheath (eg fibers that conduct the sensation of pain and touch) may be inhibited by low concentrations of the local analgesic, the blockage of the nerves in the myelin sheath requires higher concentrations. The beginning of action occurs after 2-3 minutes. General action of lidocaine: it has a stabilizing effect on cell membranes and directly on the cardiac conduction system (antiarrhythmic effect): it reduces automatism, shortens the duration of the action potential, reduces the refraction period of Purkinje cells (without reducing the conduction velocity of these cells). Lidocaine is absorbed quickly from the site of administration, especially mucous membranes. In 60-75%, it binds to plasma proteins. It penetrates the blood-brain barrier. It is metabolized in the liver - at a rate depending on the hepatic flow (about 70% during the so-called first pass), metabolites are excreted in the urine, about 3% of the drug is excreted in the urine in unchanged form. T0,5 is about 30 min.
Contraindications:
Hypersensitivity to the components of the drug or other local anesthetics with amide structure. Relative contraindications: shock, atrio-ventricular conduction block IIst. or III., myasthenia gravis, severe liver damage. Do not use in children under 4 years of age
Precautions:
Use cautiously in patients treated with tricyclic antidepressants and MAO inhibitors.
Pregnancy and lactation:
There are no data on the safety of the medicine in pregnant women and breast-feeding. Do not use during pregnancy and breastfeeding.
Side effects:
Occasionally, it can trigger an allergic reaction, rarely anaphylactic shock. Adverse reactions (taste disorders, numbness of the tongue, pain and dizziness, anxiety, increased breathing) may occur in the case of an overdose of the drug. Symptoms associated with general effects depend on the concentration of lidocaine in the serum. Likelihood of cardiovascular symptoms or o.u.n. after proper use of the gel is negligible. Undesirable effects occurring after using lidocaine may be somnolence of varying severity.
Dosage:
Apply 0.1-0.2 g of gel (ie 2-3 mm of pressed gel = 4-8 mg lidocaine) to the dried mucosa. Do not exceed the dose of lidocaine 3 mg / kg mc; in adults, do not exceed 200 mg / day (ie 4.5 g of the preparation = 8.5 cm of squeezed gel). In children, adults with low body mass and patients in poor general condition, the dose should be calculated per kg BC: the maximum daily dose - 2.9 mg / kg m.c. lidocaine.
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