Treatment of acute and chronic renal failure as a substitute fluid in hemofiltration and hemodiafiltration as well as a dialysis solution in hemodialysis and hemodiafiltration. The drug is mainly intended for use in patients with hyperkalemia.
Composition:
Composition (per 1000 ml): large chamber A: 0.343 g Calcium chloride dihydrate, 0.136 g Magnesium chloride hexahydrate, 7.66 g sodium chloride; small chamber B: 12.9 g of sodium bicarbonate. The final solution after mixing (per 1000 ml): 0.257 g calcium chloride dihydrate, 0.102 g magnesium chloride hexahydrate, 6.14 g sodium chloride, 2.94 g sodium bicarbonate. The ionic composition of the final solution (per 1000 ml): 1.75 mmol Calcium, 0.5 mmol Magnesium, 140 mmol sodium, 109.5 mmol chloride, 35 mmol bicarbonate. Theoretical osmolarity 287 mOsm / l.
Action:
Contraindications:
Contraindications depending on the composition of the solution: hypokalemia, without the simultaneous implementation of appropriate potassium supplementation; metabolic alkalosis. Contraindications depending on hemofiltration, hemodialysis or hemodiafiltration related to the technical procedure itself: renal failure accompanied by severe catabolism in patients with symptoms of uremia, which are not following haemofiltration; insufficient blood flow at the vascular access site; in the case of a high risk of haemorrhage due to the action of anticoagulants.
Precautions:
Pregnancy and lactation:
There are no data on the use of the preparation during pregnancy and lactation - use only if clearly needed.
Side effects:
Rare: hypoglycaemia (non-specific). Literature data: possible side effects associated with the treatment are: nausea, vomiting, muscle spasms, hypotension, bleeding, clotting, infection and air embolism. Possible side effects associated with the product: include metabolic alkalosis, electrolyte disturbances and / or water management disorders: hypophosphatemia, hypoglycaemia, hypo- and hypervolaemia, hypotension or hypertension.
Dosage:
For hemofiltration, hemodialysis and hemodiafiltration.As a substitution fluid. The volume of substitution fluid administered to adult patients is determined by the ultraviolet factor and is determined individually to ensure adequate fluid and electrolyte balance. Adults: chronic renal failure: 7 to 35 ml / kg / h, acute renal failure: 20 to 35 ml / kg / h. In elderly patients - dosing as in adults. The above volume recommendations can be adjusted by the attending physician according to the clinical condition of the patient. The preparation can be given to the extracorporeal circulation in pre-and post-dilution mode as prescribed by a physician.As a dialysis solution. The type and volume of the prescribed dialysis solution depend on the treatment mode, its frequency and duration; the choice is made by the physician according to the clinical condition of the patient.Administration. Hemodialysis: through the dialysis compartment of the dialyzer. Hemofiltration: via arterial or venous bloodline. The ready-to-use solution is obtained by mixing the solution contained in the large chamber "A" with the solution contained in the small chamber "B" after the splitting of the weld.
(C)
