The drug is indicated mainly in extracellular dehydration, regardless of the cause (vomiting, diarrhea, fistula, etc.); in hypovolaemia, regardless of the cause (hemorrhagic shock, burns, perioperative loss of water and electrolytes); in mild metabolic acidosis.
Composition:
500 ml of solution for infusion contains: 2.32 g of sodium acetate trihydrate, 3.01 g of sodium chloride, 0.15 g of potassium chloride and 0.15 g of Magnesium chloride hexahydrate. 1000 ml of solution for infusion contains: 4.63 g of sodium acetate trihydrate, 6.02 g of sodium chloride, 0.3 g of potassium chloride and 0.3 g of magnesium chloride hexahydrate.
Action:
Isotonic electrolyte solution. The product is used to compensate for electrolyte imbalance in serum and acid-base balance. The main effect of the action is to increase the extracellular space, including interstitial and intravascular fluid.
Contraindications:
Fluid overload (conduction), especially in the case of pulmonary edema and congestive heart failure. Severe renal failure. Metabolic alkalosis. Hyperkalemia.
Precautions:
The patient's clinical condition and laboratory parameters should be monitored (water balance, electrolytes in blood and urine as well as acid-base balance), especially when using larger volumes of solution. Avoid fluid overload caused by overdose, an increased risk of conduction occurs in patients with heart failure or severe renal impairment. Special care should be taken in patients with severe electrolyte disorders such as hypernatremia, hypermagnesaemia and hyperchloremia. In addition, caution should be exercised in patients with hypertension, heart failure, peripheral edema or pulmonary edema, renal dysfunction, pre-eclampsia, aldosteronism or other diseases, or during treatment (eg corticosteroids / steroids) associated with retention due to sodium chloride content. sodium. Potassium levels should be monitored in patients at risk of hyperkalaemia, for example in the case of severe chronic renal dysfunction. The drug should not be used in severe potassium deficiency, in the treatment of severe metabolic or respiratory acidosis. Due to the magnesium salt content, caution should be exercised in patients with renal failure, severe arrhythmia or muscle fatigue, and during postoperative administration after the use of neuromuscular blockade (due to the possibility of recurarisation). Patients should be monitored for clinical signs due to excess Magnesium, particularly during treatment of eclampsia. During long-term parenteral treatment, the patient must receive adequate nutrients.
Pregnancy and lactation:
The drug can be safely used during pregnancy and while breastfeeding, provided that the body's water and electrolyte balance is controlled.
Side effects:
When administering electrolyte solutions, conduction and heart failure have been reported in patients with cardiac disease or with pulmonary edema (very common) and swelling caused by water / sodium overload (frequency not known). In addition, fever, infection at the injection site, local pain or reaction, vein irritation, vein thrombosis or phlebitis spreading from the injection site and extravasation may occur. At high doses, the dilution effect can often lead to similar dilutions of blood components, e.g. clotting factors and other plasma proteins, and to the reduction of the hematocrit. If an adverse reaction occurs, the infusion should be discontinued.
Dosage:
Intravenously, in the form of an infusion. The dose and rate of infusion depends on the age, body weight, clinical condition and biological parameters of the patient and the combination therapy. The maximum daily dose corresponds to the patient's need for fluids and electrolytes. For temporary blood replenishment, it is necessary to give a 3- to 5-fold volume greater than the amount of blood lost. Adults, adolescents ≥12.lat: 0.5-3 l / 24 h, in long-term treatment (except severe fluid loss), the infusion rate is usually 40 ml / kg / 24 h. Newborns, infants, children <11 years: 20-100 ml / kg m / 24 h, infusion rate: newborns 6-8 ml / kg / h; infants 4-6 ml / kg / h; school-aged children 2-4 ml / kg / h.
(C)
