Prevention and treatment of vitamin C deficiency in cases when the use of a proper diet is not enough.
Composition:
1 ml (about 20 drops) contains 100 mg ascorbic acid.
Action:
Vitamin C is a substance indispensable for humans. Ascorbic and dehydroascorbic acid form an oxidation-reduction system. Vitamin C has a high oxidation-reduction potential, it participates as a co-factor in many enzyme systems, e.g. collagen synthesis, catecholamine synthesis, steroid hydroxylation, tyrosine and exogenous substances, Carnitine biosynthesis, tetrahydrofolic acid regeneration and peptide amidiatization. Vitamin C deficiency also affects immune system reactions, especially chemotaxis, complement activation and Interferon production. Ascorbic acid increases the absorption of iron salts thanks to the reduction of iron III ions and the formation of chelate compounds and inhibits free radical chains. Its antioxidant activity remains in close biochemical relationship with the antioxidant effect of vitamin E, vitamin A and carotenoids. Ascorbic acid is absorbed to a limited extent, the absorption depends on the concentration in the proximal section of the small intestine. As the single dose increases, bioavailability decreases from 60-75% to 1g, to about 40% at 3g and to about 16% at 12g. The unabsorbed amount of vitamin C is degraded by the bacterial flora of the large intestine. A significant portion of ascorbic acid is reversibly oxidized to dehydroascorbate in the liver. Inactive metabolites (i.e., 2-ascorbate and oxalate sulfate) are produced in a smaller amount and excreted in the urine. Ascorbic acid is excreted mainly in the urine (> 80%) in unchanged form. T0,5 is 2.9 hours.
Contraindications:
Hypersensitivity to ascorbic acid or to any of the excipients. Kidney stones. Increased level of uric acid in the past. Disturbances in iron storage (thalassemia, hemochromatosis, anaphylactic anemia). Peptic ulcer disease.
Precautions:
In patients with a deficiency of erythrocyte glucose-6-phosphate dehydrogenase, high doses of ascorbic acid (4 g / day) may cause haemolysis. Patients with severe or end-stage renal disease (dialysis patients) should not exceed the daily intake of 100 mg Ascorbic acid, due to the risk of developing urinary stones.
Pregnancy and lactation:
Ascorbic acid penetrates the placental barrier and into human milk. Do not use in pregnancy without medical supervision. Do not exceed the set dose while breastfeeding.
Side effects:
In individual cases, skin and respiratory hypersensitivity reactions have been observed. After high doses, headache, gastrointestinal disorders (eg, nausea, vomiting, diarrhea, abdominal pain, indigestion) and polyuria were reported. Prolonged use of high doses may cause kidney stones.
Dosage:
Orally. In children up to 3 years of age, the drug should be administered after consultation with a doctor. If there is no need for a different dosage, the following doses are given - infants and young children (from the 28th day of life to the end of the 23rd month): 5-8 drops per day, preferably adding drops to the bottle or a tablespoon of milk, tea or juice fruit; children from 24. mż. until the end of 11: 10 drops a day; adolescents from 12 years of age and adults: 15-20 drops per day. If required, the given doses may be taken twice a day.
(C)
