B vitamin deficiency states6. Diseases and conditions requiring administration of pyridoxine: peripheral polyneuropathies, prevention of peripheral neuropathy during isoniazid use, use of oral contraceptives, congenital metabolic disorders (cystationinuria, homocystinuria, hyperoxaluria, xanthuren acanthuria), malabsorption syndromes eg in liver diseases caused by alcoholism, sunburn and post-inflammatory skin pigmentation changes (preventive), inflammation of the skin and mucous membranes of the mouth (including akrodynia) and tongue inflammation, exfoliative erytroderma, seborrhea, paradontopathies, isoniazid poisoning, cycloserine intoxication. Auxiliary: sideroblastic anemia, leukopenia and agranulocytosis, nausea and vomiting of pregnant women, depressive states, sleep disorders (insomnia), vegetative neurosis (as a mild symptomatic drug, tranquilizer), radiation sickness.
Composition:
1 tabl contains 50 mg of Pyridoxine hydrochloride. The product contains lactose and sucrose.
Action:
Pyridoxine - vitamin B6 is a coenzyme that participates in amino acid transformation and protein synthesis - it determines the activity of over 60 different enzymes. Particularly important is its participation in the transformation of tryptophan, which produces serotonin and nicotinic acid. It is essential in the process of phosphorylation, affects glycogenesis and glycogenolysis in muscles, plays an important role in immune and hematopoietic processes. It reduces the prolactin secretion. Symptoms of pyridoxine deficiency are nonspecific: skin lesions, inflammation of the tongue and oral mucosa, seizures, microcytic anemia non-pigmented or megaloblastic, polyneuritis, depression. Its lack may favor the development of oxalate urolithiasis. Pyridoxine is well absorbed from the gastrointestinal tract. It excretes in the urine, mainly in the form of metabolites. T0,5 is 15-20 days.
Contraindications:
Hypersensitivity to pyridoxine or other components of the preparation. The use of levodopa preparations without a dopa-decarboxylase inhibitor (in the treatment of Parkinson's disease).
Precautions:
Due to the lactose and sucrose content, the preparation should not be used in patients with galactose and fructose intolerance, Lapp lactase deficiency and sucrase-isomaltase deficiency or glucose-galactose malabsorption.
Pregnancy and lactation:
The preparation can be used during pregnancy and during breastfeeding at the recommended doses. During pregnancy, the dose of 50 mg per day should not be exceeded. Larger doses should be used periodically only in cases where the benefit to the mother outweighs the potential risk to the fetus or newborn infant being breastfed. There are no data on the occurrence of congenital malformations in children whose mothers received high doses of vitamin B6. However, you should consider the possibility of a vitamin B addiction syndrome6 in children of women who take large doses of pyridoxine during pregnancy. After delivery, you may experience seizures associated with this vitamin in the fetus.
Side effects:
Rare: allergic and photosensitizing reactions. Not known: hypersensitivity reactions. The use of pyridoxine in doses of 200 mg for over a month may lead to the development of the dependence syndrome. Large doses used for a long time may cause sleep disturbances and peripheral sensory neuropathy.
Dosage:
Orally. Adults: 50-100 mg 3 times a day. Prevention of peripheral neuropathy with isoniazid: 50 mg once daily. Prevention of sunburn and post-burn skin pigmentation: 150-200 mg once or in divided doses. Metabolic disorders - up to 450 mg per day in 3 divided doses. Radiation radiation: 50-100 mg daily. For help in the treatment of insomnia and vegetative neurosis: 50-300 mg daily in divided doses. Children: 25-150 mg daily in 2-3 divided doses. Do not exceed the maximum daily dose.
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