Magnesium is an element necessary in the normal course of metabolic processes in the body. It participates in enzymatic reactions dependent on ATPase and is a stabilizer of cell membranes and intracellular organelles. Magnesium is a mineral component of all body tissues. He participates in the proper functioning of the nervous, bone-joint, respiratory, cardiovascular, hormonal, hematopoietic and immune systems. It affects the activity of the auditory and visual nerves. It reduces the susceptibility to stress (in the absence of emotional balance, anxiety, fatigue associated with premenstrual syndrome, depression, migraine, during intense mental effort), reduces neuromuscular excitability (in neuromuscular hyperactivity, hyperactivity disorder in children, increased of physical activity - hard physical work, doing sports), determines the proper muscle contractility (eg in the night cramps of the calves), has a protective effect on the heart muscle (heart failure, hypertension), counteracts myocardial ischemia. Magnesium is necessary for the proper bone mineralization and secretion of parathyroid hormone during the period of intensive growth of children and adolescents. Vitamin B included in the preparation6 provides a favorable absorption profile for magnesium aspartate. Magnesium asparaginate tetrahydrate is a highly soluble compound that promotes absorption. Magnesium absorption takes place in the small intestine, parallel to the absorption of water. The process is favored by a sour diet rich in proteins (especially animal), unsaturated fats, small amounts of vitamin B6, sodium, lactose and vitamin D. The concentration of magnesium in the cell is about 10 times higher than in the extracellular fluid. Magnesium is mainly excreted in the urine and partially reabsorbed in the renal tubules. Demand for magnesium in an adult human is about 5 mg / kg. per day (ie 270-350 mg, or 11-14 mmol Mg)2+). In conditions of major deficiencies, as well as in the period of intense physical effort, rapid growth in children, in pregnant women and nursing women, the demand increases to 7-10 mg / kg. Vitamin B6 after absorption, it is transformed into the active coenzyme pyridoxal 5-phosphate. It is mainly stored in the liver and excreted in the urine. Pyridoxine increases the absorption of magnesium from the digestive tract.
Contraindications:
Hypersensitivity to the active substances or to any of the excipients. Hypermagnesaemia. acute renal failure. Significant hypotension. Atrioventricular block.Myasthenia gravis.
Precautions:
With long-term use, control the concentration of magnesium in the serum. A preparation used in a dose higher than the recommended dose may cause diarrhea.
Pregnancy and lactation:
At the recommended doses, the preparation can be used during pregnancy and breastfeeding only if clearly necessary.
Side effects:
The following may occur: atrioventricular conduction abnormalities, redness of the skin. Sometimes nausea and diarrhea may occur, which usually disappear spontaneously.
Dosage:
Orally.Magnesium and vitamin B deficiency6. Adults and children over 12 years of age: usually 1-2 tabl. 3 times a day. Children under 12 years of age: usually 1 tabl. 3 times a day.Prevention. Adults and children over 12 years of age: usually 1-2 tabl. once a day. If you increase the dose, consult your doctor. The preparation should be taken after a meal with a small amount of liquid.
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